P08638

SS
Gene name
LEU3 (YLR451W, L9324.1)
Protein name
Regulatory protein LEU3
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR451W
EC number
Protein Class

Descriptions

Leu3p belongs to a family of proteins characterized by an N-terminal DNA binding domain of the Zn(II)2Cys6 binuclear cluster type. The mutations within the autoinhibitory region were found to make Leu3p constutively active.

Autoinhibitory domains (AIDs)

604-741 (Autoinhibitory region) SS

Target domain

855-886 (Transactivation domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P08638

Entry ID Method Resolution Chain Position Source
2ER8 X-ray 285 A A/B/C/D 32-103 PDB
2ERE X-ray 300 A A/B 32-103 PDB
2ERG X-ray 315 A A/B 32-103 PDB
AF-P08638-F1 Predicted AlphaFoldDB

18 variants for P08638

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-1036109 7 F>S No SGRP
s12-1036148 20 S>N No SGRP
s12-1036372 95 T>A No SGRP
s12-1036565 159 R>K No SGRP
s12-1036849 254 G>W No SGRP
s12-1036900 271 S>A No SGRP
s12-1037182 365 V>I No SGRP
s12-1037551 488 S>G No SGRP
s12-1038168 693 E>D No SGRP
s12-1038167 693 E>G No SGRP
s12-1038185 699 S>T No SGRP
s12-1038197 703 P>L No SGRP
s12-1038207 706 M>I No SGRP
s12-1038323 745 T>I No SGRP
s12-1038358 757 Q>K No SGRP
s12-1038542 818 T>I No SGRP
s12-1038625 846 V>I No SGRP
s12-1038628 847 T>A No SGRP

No associated diseases with P08638

1 regional properties for P08638

Type Name Position InterPro Accession
domain Zn(2)Cys(6) fungal-type DNA-binding domain 31 - 78 IPR001138

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of leucine biosynthetic process Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription, DNA-templated Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGRSDFVAT SQSGSEMSHS ETRNRTGMNA RKRKFACVEC RQQKSKCDAH ERAPEPCTKC
70 80 90 100 110 120
AKKNVPCILK RDFRRTYKRA RNEAIEKRFK ELTRTLTNLT SDEILKKIEE EQEIVLDNSN
130 140 150 160 170 180
FTKEKVKQLR KSAFETTEIE PRSYKTLRGE PISYSTNRRH TDSSPLTLLS SSTNFDPVHS
190 200 210 220 230 240
TNVMTDDQLK CLPKSLGDVY LSSSDIAELF QEFATKYHQF LPVVDLSKGA ERIYHLSPCL
250 260 270 280 290 300
FWVILLIGLR RKFGATDLMT RLSVLVKSVL SEITISPIIR YTPSDKDEPV LNVASVYSVQ
310 320 330 340 350 360
AFLLYTFWPP LTSSLSADTS WNTIGTAMFQ ALRVGLNCAG FSKEYASANS ELVNEQIRTW
370 380 390 400 410 420
ICCNVVSQTV ASSFGFPAYV SFDYLVISSI RVPNSKSQVD IPNELRQMAQ IARFENQIVN
430 440 450 460 470 480
TMNSTPASVT GMVSQEEKQP LLHVLNQQLS QLEISLEENN LDDIRKFLLL VAKVHLLTYY
490 500 510 520 530 540
FTDVTSQSAG KSNGNIYEGS YSIMELDTSF ETKRGLVKVY NAAVNFLIHA NSMWEHDPTI
550 560 570 580 590 600
IKYFPGLFVL NIWQSACIIS KLIHSSLHSM LDVNSGKKAY NNAISLTFNA SVLKYDMAYR
610 620 630 640 650 660
SSGIMRSIWS LFANMYDAWK NDQKEGGGRL NNDFNLGITI KSRMSVNVFF DCLYILKEKC
670 680 690 700 710 720
GMAKLERETK VSTAYNVDEE EEEDEDEEGE EEEEEEELSS KVPENMDSQQ LRTRKFTNVR
730 740 750 760 770 780
HPEKKARKII ETIPLDPNPI NAGSTSSGSS LTTPNSQVAN TISYRGILNK MSPREQLNHA
790 800 810 820 830 840
NLDSSVSTDI KDTEAVNEPL PIGRNAEHPA NQPPLSITQM QENTLPATQA NSSLLETYPI
850 860 870 880
VQSNPVTTTI KESPNSIMAG WDNWESDMVW RDVDILMNEF AFNPKV