P08308

PR
Gene name
arcB
Protein name
Ornithine carbamoyltransferase, catabolic
Names
OTCase
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA5172
EC number
2.1.3.3: Carboxy- and carbamoyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P08308

Entry ID Method Resolution Chain Position Source
1DXH X-ray 250 A A 2-336 PDB
1ORT X-ray 300 A A/B/C/D/E/F/G/H/I/J/K/L 2-336 PDB
AF-P08308-F1 Predicted AlphaFoldDB

No variants for P08308

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P08308

No associated diseases with P08308

2 regional properties for P08308

Type Name Position InterPro Accession
domain Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain 156 - 331 IPR006131
domain Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding 8 - 148 IPR006132

Functions

Description
EC Number 2.1.3.3 Carboxy- and carbamoyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
ornithine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

4 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.
arginine catabolic process to ornithine The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.
arginine deiminase pathway The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase.
citrulline biosynthetic process The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAFNMHNRNL LSLMHHSTRE LRYLLDLSRD LKRAKYTGTE QQHLKRKNIA LIFEKTSTRT
70 80 90 100 110 120
RCAFEVAAYD QGANVTYIDP NSSQIGHKES MKDTARVLGR MYDAIEYRGF KQEIVEELAK
130 140 150 160 170 180
FAGVPVFNGL TDEYHPTQML ADVLTMREHS DKPLHDISYA YLGDARNNMG NSLLLIGAKL
190 200 210 220 230 240
GMDVRIAAPK ALWPHDEFVA QCKKFAEESG AKLTLTEDPK EAVKGVDFVH TDVWVSMGEP
250 260 270 280 290 300
VEAWGERIKE LLPYQVNMEI MKATGNPRAK FMHCLPAFHN SETKVGKQIA EQYPNLANGI
310 320 330
EVTEDVFESP YNIAFEQAEN RMHTIKAILV STLADI