P08244

PR
Gene name
pyrF (b1281, JW1273)
Protein name
Orotidine 5'-phosphate decarboxylase
Names
OMP decarboxylase, OMPDCase, OMPdecase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1281
EC number
4.1.1.23: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P08244

Entry ID Method Resolution Chain Position Source
1EIX X-ray 250 A A/B/C/D 1-245 PDB
1JJK X-ray 300 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-245 PDB
1L2U X-ray 250 A A/B 1-245 PDB
AF-P08244-F1 Predicted AlphaFoldDB

No variants for P08244

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P08244

No associated diseases with P08244

2 regional properties for P08244

Type Name Position InterPro Accession
domain Orotidine 5'-phosphate decarboxylase domain 15 - 237 IPR001754
active_site Orotidine 5'-phosphate decarboxylase, active site 68 - 81 IPR018089

Functions

Description
EC Number 4.1.1.23 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.

3 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.
nucleobase-containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTLTASSSSR AVTNSPVVVA LDYHNRDDAL AFVDKIDPRD CRLKVGKEMF TLFGPQFVRE
70 80 90 100 110 120
LQQRGFDIFL DLKFHDIPNT AAHAVAAAAD LGVWMVNVHA SGGARMMTAA REALVPFGKD
130 140 150 160 170 180
APLLIAVTVL TSMEASDLVD LGMTLSPADY AERLAALTQK CGLDGVVCSA QEAVRFKQVF
190 200 210 220 230 240
GQEFKLVTPG IRPQGSEAGD QRRIMTPEQA LSAGVDYMVI GRPVTQSVDP AQTLKAINAS
LQRSA