| antigen processing and presentation of exogenous peptide antigen via MHC class II |
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. |
| B cell proliferation |
The expansion of a B cell population by cell division. Follows B cell activation. |
| cell surface receptor signaling pathway |
The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| cellular response to amyloid-beta |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. |
| cellular response to molecule of bacterial origin |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. |
| cerebellum development |
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
| defense response |
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| dendrite development |
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. |
| endocytic recycling |
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| establishment of localization in cell |
Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| Fc receptor-mediated immune complex endocytosis |
An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I. |
| immune complex clearance |
A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. |
| immunoglobulin mediated immune response |
An immune response mediated by immunoglobulins, whether cell-bound or in solution. |
| negative regulation of acute inflammatory response to antigenic stimulus |
Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus. |
| negative regulation of B cell proliferation |
Any process that stops, prevents or reduces the rate or extent of B cell proliferation. |
| negative regulation of humoral immune response mediated by circulating immunoglobulin |
Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin. |
| negative regulation of immune response |
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
| negative regulation of immunoglobulin production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. |
| negative regulation of inflammatory response to antigenic stimulus |
Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. |
| negative regulation of interleukin-10 production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. |
| negative regulation of neutrophil apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process. |
| negative regulation of phagocytosis |
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. |
| negative regulation of type I hypersensitivity |
Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response. |
| phagocytosis |
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| phagocytosis, engulfment |
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. |
| positive regulation of DNA-binding transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of JNK cascade |
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| positive regulation of neuron death |
Any process that activates or increases the frequency, rate or extent of neuron death. |
| positive regulation of phagocytosis |
Any process that activates or increases the frequency, rate or extent of phagocytosis. |
| positive regulation of response to endoplasmic reticulum stress |
Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress. |
| receptor-mediated endocytosis |
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. |
| regulation of dendritic spine maintenance |
Any process that modulates the frequency, rate or extent of dendritic spine maintenance. |
| regulation of immune response |
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
| regulation of long-term neuronal synaptic plasticity |
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. |
| response to bacterium |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
