P08092

PR
Gene name
ran1 (pat1, SPBC19C2.05)
Protein name
Negative regulator of sexual conjugation and meiosis
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC19C2.05
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

291-460 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

161-181 (Activation loop from InterPro)

Target domain

18-302 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P08092

Entry ID Method Resolution Chain Position Source
AF-P08092-F1 Predicted AlphaFoldDB

No variants for P08092

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P08092

No associated diseases with P08092

3 regional properties for P08092

Type Name Position InterPro Accession
domain Protein kinase domain 18 - 302 IPR000719
active_site Serine/threonine-protein kinase, active site 139 - 151 IPR008271
binding_site Protein kinase, ATP binding site 24 - 47 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
cell cycle G1/S phase transition The cell cycle process by which a cell in G1 phase commits to S phase.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
negative regulation of cell cycle switching, mitotic to meiotic cell cycle Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.
negative regulation of induction of conjugation with cellular fusion Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion.
negative regulation of protein import into nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of G1/S transition of mitotic cell cycle Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMRENPELLL GQVLGDSLRF VSIIGAGAYG VVYKAEDIYD GTLYAVKALC KDGLNEKQKK
70 80 90 100 110 120
LQARELALHA RVSSHPYIIT LHRVLETEDA IYVVLQYCPN GDLFTYITEK KVYQGNSHLI
130 140 150 160 170 180
KTVFLQLISA VEHCHSVGIY HRDLKPENIM VGNDVNTVYL ADFGLATTEP YSSDFGCGSL
190 200 210 220 230 240
FYMSPECQRE VKKLSSLSDM LPVTPEPIES QSSSFATAPN DVWALGIILI NLCCKRNPWK
250 260 270 280 290 300
RACSQTDGTY RSYVHNPSTL LSILPISREL NSLLNRIFDR NPKTRITLPE LSTLVSNCKN
310 320 330 340 350 360
LTRRLRPAPL VSSRYLAYQQ QQQQQQMNLQ QGIQGYPHQG YMPTQNIGFP WPPTPQFVSN
370 380 390 400 410 420
WNHCATPTIP VSLQVLTPNS SLKVDPTTPL TAPIHATESF WPSAAAAAAA VHNNANSYMP
430 440 450 460
ITPTPYPNNA KIFGYPNQPP LTPIPFTGFV LHPAPVGRAA DAVDPSRKSL