P07382

PR
Gene name
LmjF06.0860 (LmjF_06_0860)
Protein name
Bifunctional dihydrofolate reductase-thymidylate synthase
Names
DHFR-TS
Species
Leishmania major
KEGG Pathway
lma:LMJF_06_0860
EC number
1.5.1.3: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P07382

Entry ID Method Resolution Chain Position Source
AF-P07382-F1 Predicted AlphaFoldDB

No variants for P07382

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P07382

No associated diseases with P07382

4 regional properties for P07382

Type Name Position InterPro Accession
domain Dihydrofolate reductase domain 26 - 229 IPR001796
conserved_site Dihydrofolate reductase conserved site 38 - 60 IPR017925
active_site Thymidylate synthase, active site 380 - 408 IPR020940
domain Thymidylate synthase/dCMP hydroxymethylase domain 236 - 520 IPR023451

Functions

Description
EC Number 1.5.1.3 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.

4 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
methylation The process in which a methyl group is covalently attached to a molecule.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRAAARFKI PMPETKADFA FPSLRAFSIV VALDMQHGIG DGESIPWRVP EDMTFFKNQT
70 80 90 100 110 120
TLLRNKKPPT EKKRNAVVMG RKTWESVPVK FRPLKGRLNI VLSSKATVEE LLAPLPEGQR
130 140 150 160 170 180
AAAAQDVVVV NGGLAEALRL LARPLYCSSI ETAYCVGGAQ VYADAMLSPC IEKLQEVYLT
190 200 210 220 230 240
RIYATAPACT RFFPFPPENA ATAWDLASSQ GRRKSEAEGL EFEICKYVPR NHEERQYLEL
250 260 270 280 290 300
IDRIMKTGIV KEDRTGVGTI SLFGAQMRFS LRDNRLPLLT TKRVFWRGVC EELLWFLRGE
310 320 330 340 350 360
TSAQLLADKD IHIWDGNGSR EFLDSRGLTE NKEMDLGPVY GFQWRHFGAD YKGFEANYDG
370 380 390 400 410 420
EGVDQIKLIV ETIKTNPNDR RLLVTAWNPC ALQKMALPPC HLLAQFYVNT DTSELSCMLY
430 440 450 460 470 480
QRSCDMGLGV PFNIASYALL TILIAKATGL RPGELVHTLG DAHVYRNHVD ALKAQLERVP
490 500 510
HAFPTLIFKE ERQYLEDYEL TDMEVIDYVP HPAIKMEMAV