P07287

PR
Gene name
ermE (SACE_0733)
Protein name
rRNA adenine N-6-methyltransferase
Names
NMT, Erythromycin resistance protein, Macrolide-lincosamide-streptogramin B resistance protein
Species
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
KEGG Pathway
sen:SACE_0733
EC number
2.1.1.184: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

264-381 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P07287

Entry ID Method Resolution Chain Position Source
6NVM X-ray 175 A A 1-290 PDB
AF-P07287-F1 Predicted AlphaFoldDB

No variants for P07287

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P07287

No associated diseases with P07287

2 regional properties for P07287

Type Name Position InterPro Accession
conserved_site Ribosomal RNA adenine methylase transferase, conserved site 65 - 92 IPR020596
domain Ribosomal RNA adenine methylase transferase, N-terminal 49 - 213 IPR020598

Functions

Description
EC Number 2.1.1.184 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.

1 GO annotations of biological process

Name Definition
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSDEQPRP RRRNQDRQHP NQNRPVLGRT ERDRNRRQFG QNFLRDRKTI ARIAETAELR
70 80 90 100 110 120
PDLPVLEAGP GEGLLTRELA DRARQVTSYE IDPRLAKSLR EKLSGHPNIE VVNADFLTAE
130 140 150 160 170 180
PPPEPFAFVG AIPYGITSAI VDWCLEAPTI ETATMVTQLE FARKRTGDYG RWSRLTVMTW
190 200 210 220 230 240
PLFEWEFVEK VDRRLFKPVP KVDSAIMRLR RRAEPLLEGA ALERYESMVE LCFTGVGGNI
250 260 270 280 290 300
QASLLRKYPR RRVEAALDHA GVGGGAVVAY VRPEQWLRLF ERLDQKNEPR GGQPQRGRRT
310 320 330 340 350 360
GGRDHGDRRT GGQDRGDRRT GGRDHRDRQA SGHGDRRSSG RNRDDGRTGE REQGDQGGRR
370 380
GPSGGGRTGG RPGRRGGPGQ R