P07178

PR
Gene name
HARS1 (HARS, HRS)
Protein name
Histidine--tRNA ligase, cytoplasmic
Names
Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, Histidyl-tRNA synthetase, HisRS
Species
Mesocricetus auratus (Golden hamster)
KEGG Pathway
EC number
6.1.1.21: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P07178

Entry ID Method Resolution Chain Position Source
AF-P07178-F1 Predicted AlphaFoldDB

No variants for P07178

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P07178

No associated diseases with P07178

4 regional properties for P07178

Type Name Position InterPro Accession
domain WHEP-TRS domain 3 - 60 IPR000738
domain Anticodon-binding 410 - 499 IPR004154
domain Histidyl-anticodon-binding 407 - 498 IPR033656
domain Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain 61 - 393 IPR041715

Functions

Description
EC Number 6.1.1.21 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
protein homodimerization activity Binding to an identical protein to form a homodimer.

1 GO annotations of biological process

Name Definition
histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASPALEELV LNSRHRLVRG LKQQKASADQ IEEEVAKLLK LKAQLGHDES KQKFVLKTPK
70 80 90 100 110 120
GTRDYSPRQM AVREKVFDVI ICCFKRHGAE VIDTPVFELK ETLMGKYGQD CKLIYDLKDQ
130 140 150 160 170 180
GGELLSLRYD LTVPFGRYLA MNNLTNIKRY HIAKVYRRDN PAMTRGRYLN SITVDFDIAG
190 200 210 220 230 240
QFDPMIPDAE CLKIMCEILS SLQIGKFLVK VNDRRILDGM FAVCGVPDSK FRTICSSVDK
250 260 270 280 290 300
LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGEVCLV EQLLQDPKLS QNKQAVEGLG
310 320 330 340 350 360
DLKLLFEYLT LFGIDDKISF DLSLARGLDY YTGVIYVAVL LQMPTGAGEE PWCGQCGCWR
370 380 390 400 410 420
RYDGLVGMFD PKGRKVPCVG LSIGVERIFS IVEQRLEALE EKVRTTETQV LVASAQKKLA
430 440 450 460 470 480
GGETKACLQL WDAGIKAELL YKKNPKLLNQ LQYCEETGIP LVAIIGEQEL KDGVIKLRSV
490 500
ASREEVDVRR EDLVEEIRRR TNQPLYVC