P07149

PR
Gene name
FAS1 (YKL182W)
Protein name
Fatty acid synthase subunit beta
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKL182W
EC number
1.3.1.9: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

107-176 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

29 structures for P07149

Entry ID Method Resolution Chain Position Source
2PFF X-ray 400 A PDB
2UV8 X-ray 310 A G/H/I 1-2051 PDB
2VKZ X-ray 400 A G/H/I 1-2051 PDB
3HMJ X-ray 400 A G/H/I 1-2051 PDB
6JSH EM 510 A B/F/G 1-2051 PDB
6JSI EM 470 A B/F/G 1-2051 PDB
6QL5 EM 280 A G/H/I/J/K/L 5-2050 PDB
6QL6 EM 290 A G/H/I/J/K/L 5-2050 PDB
6QL7 X-ray 460 A G/H/I/J/K/L/g/h/i/j/k/l 1-2051 PDB
6QL9 X-ray 282 A G/H/I/J/K/L 1-2051 PDB
6TA1 EM 310 A C/E/G/H/J/L 1-2051 PDB
6U5T EM 290 A G 1-2051 PDB
6U5U EM 280 A G 1-2051 PDB
6WC7 EM 580 A G 1-2051 PDB
8PRV EM 290 A G 1-2051 PDB
8PRW EM 190 A G/H/I/J/K/L 1-2051 PDB
8PS1 EM 280 A G 1-2051 PDB
8PS2 EM 290 A G 1-2051 PDB
8PS8 EM 400 A G 1-2051 PDB
8PS9 EM 290 A G 1-2051 PDB
8PSA EM 360 A G 1-2051 PDB
8PSF EM 280 A G 1-2051 PDB
8PSG EM 370 A G 1-2051 PDB
8PSJ EM 340 A G 1-2051 PDB
8PSK EM 280 A G 1-2051 PDB
8PSL EM 370 A G 1-2051 PDB
8PSM EM 310 A G 1-2051 PDB
8PSP EM 290 A G 1-2051 PDB
AF-P07149-F1 Predicted AlphaFoldDB

15 variants for P07149

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-101188 171 E>D No SGRP
s11-101511 279 T>I No SGRP
s11-102458 595 P>A No SGRP
s11-102533 620 A>S No SGRP
s11-102609 645 S>N No SGRP
s11-102803 710 I>V No SGRP
s11-103206 844 V>A No SGRP
s11-103680 1002 H>R No SGRP
s11-103751 1026 E>Q No SGRP
s11-104037 1121 S>F No SGRP
s11-104316 1214 L>S No SGRP
s11-104323 1216 E>D No SGRP
s11-105858 1728 R>K No SGRP
s11-105878 1735 A>S No SGRP
s11-106659 1995 N>S No SGRP

No associated diseases with P07149

19 regional properties for P07149

Type Name Position InterPro Accession
domain MaoC-like dehydratase domain 1523 - 1647 IPR002539
domain Fatty acid synthase 581 - 601 IPR003965-1
domain Fatty acid synthase 607 - 625 IPR003965-2
domain Fatty acid synthase 706 - 724 IPR003965-3
domain Fatty acid synthase 726 - 745 IPR003965-4
domain Fatty acid synthase 913 - 931 IPR003965-5
domain Fatty acid synthase 1012 - 1036 IPR003965-6
domain Fatty acid synthase 1547 - 1569 IPR003965-7
domain Fatty acid synthase 1569 - 1590 IPR003965-8
domain Fatty acid synthase 1654 - 1673 IPR003965-9
domain Fatty acid synthase 1675 - 1698 IPR003965-10
domain Fatty acid synthase 1796 - 1815 IPR003965-11
domain Fatty acid synthase 1832 - 1853 IPR003965-12
domain Fatty acid synthase beta subunit AflB /Fas1-like, central domain 727 - 1074 IPR013565
domain Acyl transferase 1663 - 2037 IPR014043
domain Starter unit:ACP transacylase 159 - 412 IPR032088
domain N-terminal of MaoC-like dehydratase 1285 - 1405 IPR039569
domain Fatty acid synthase, meander beta sheet domain 1134 - 1272 IPR040883
domain Fatty acid synthase subunit beta, N-terminal domain 5 - 131 IPR041099

Functions

Description
EC Number 1.3.1.9 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

15 GO annotations of molecular function

Name Definition
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: a (3R)-3-hydroxyacyl-
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxydecanoyl-
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-
[acyl-carrier-protein] S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA
[acyl-carrier-protein] S-malonyltransferase activity +Catalysis of the reaction: malonyl-CoA
enoyl-[acyl-carrier-protein] reductase (NADH) activity +Catalysis of the reaction: acyl-
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Catalysis of the reaction: acyl-
enoyl-[acyl-carrier-protein] reductase activity Catalysis of the reaction: acyl- + NAD(P)+ = trans-2,3-dehydroacyl- + NAD(P)H + H+.
fatty-acyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
myristoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: myristoyl-
oleoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: oleoyl-
palmitoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: palmitoyl-
palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (CH3-14-CO-) group to an acceptor molecule.

1 GO annotations of biological process

Name Definition
long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDAYSTRPLT LSHGSLEHVL LVPTASFFIA SQLQEQFNKI LPEPTEGFAA DDEPTTPAEL
70 80 90 100 110 120
VGKFLGYVSS LVEPSKVGQF DQVLNLCLTE FENCYLEGND IHALAAKLLQ ENDTTLVKTK
130 140 150 160 170 180
ELIKNYITAR IMAKRPFDKK SNSALFRAVG EGNAQLVAIF GGQGNTDDYF EELRDLYQTY
190 200 210 220 230 240
HVLVGDLIKF SAETLSELIR TTLDAEKVFT QGLNILEWLE NPSNTPDKDY LLSIPISCPL
250 260 270 280 290 300
IGVIQLAHYV VTAKLLGFTP GELRSYLKGA TGHSQGLVTA VAIAETDSWE SFFVSVRKAI
310 320 330 340 350 360
TVLFFIGVRC YEAYPNTSLP PSILEDSLEN NEGVPSPMLS ISNLTQEQVQ DYVNKTNSHL
370 380 390 400 410 420
PAGKQVEISL VNGAKNLVVS GPPQSLYGLN LTLRKAKAPS GLDQSRIPFS ERKLKFSNRF
430 440 450 460 470 480
LPVASPFHSH LLVPASDLIN KDLVKNNVSF NAKDIQIPVY DTFDGSDLRV LSGSISERIV
490 500 510 520 530 540
DCIIRLPVKW ETTTQFKATH ILDFGPGGAS GLGVLTHRNK DGTGVRVIVA GTLDINPDDD
550 560 570 580 590 600
YGFKQEIFDV TSNGLKKNPN WLEEYHPKLI KNKSGKIFVE TKFSKLIGRP PLLVPGMTPC
610 620 630 640 650 660
TVSPDFVAAT TNAGYTIELA GGGYFSAAGM TAAIDSVVSQ IEKGSTFGIN LIYVNPFMLQ
670 680 690 700 710 720
WGIPLIKELR SKGYPIQFLT IGAGVPSLEV ASEYIETLGL KYLGLKPGSI DAISQVINIA
730 740 750 760 770 780
KAHPNFPIAL QWTGGRGGGH HSFEDAHTPM LQMYSKIRRH PNIMLIFGSG FGSADDTYPY
790 800 810 820 830 840
LTGEWSTKFD YPPMPFDGFL FGSRVMIAKE VKTSPDAKKC IAACTGVPDD KWEQTYKKPT
850 860 870 880 890 900
GGIVTVRSEM GEPIHKIATR GVMLWKEFDE TIFNLPKNKL VPTLEAKRDY IISRLNADFQ
910 920 930 940 950 960
KPWFATVNGQ ARDLATMTYE EVAKRLVELM FIRSTNSWFD VTWRTFTGDF LRRVEERFTK
970 980 990 1000 1010 1020
SKTLSLIQSY SLLDKPDEAI EKVFNAYPAA REQFLNAQDI DHFLSMCQNP MQKPVPFVPV
1030 1040 1050 1060 1070 1080
LDRRFEIFFK KDSLWQSEHL EAVVDQDVQR TCILHGPVAA QFTKVIDEPI KSIMDGIHDG
1090 1100 1110 1120 1130 1140
HIKKLLHQYY GDDESKIPAV EYFGGESPVD VQSQVDSSSV SEDSAVFKAT SSTDEESWFK
1150 1160 1170 1180 1190 1200
ALAGSEINWR HASFLCSFIT QDKMFVSNPI RKVFKPSQGM VVEISNGNTS SKTVVTLSEP
1210 1220 1230 1240 1250 1260
VQGELKPTVI LKLLKENIIQ MEMIENRTMD GKPVSLPLLY NFNPDNGFAP ISEVMEDRNQ
1270 1280 1290 1300 1310 1320
RIKEMYWKLW IDEPFNLDFD PRDVIKGKDF EITAKEVYDF THAVGNNCED FVSRPDRTML
1330 1340 1350 1360 1370 1380
APMDFAIVVG WRAIIKAIFP NTVDGDLLKL VHLSNGYKMI PGAKPLQVGD VVSTTAVIES
1390 1400 1410 1420 1430 1440
VVNQPTGKIV DVVGTLSRNG KPVMEVTSSF FYRGNYTDFE NTFQKTVEPV YQMHIKTSKD
1450 1460 1470 1480 1490 1500
IAVLRSKEWF QLDDEDFDLL NKTLTFETET EVTFKNANIF SSVKCFGPIK VELPTKETVE
1510 1520 1530 1540 1550 1560
IGIVDYEAGA SHGNPVVDFL KRNGSTLEQK VNLENPIPIA VLDSYTPSTN EPYARVSGDL
1570 1580 1590 1600 1610 1620
NPIHVSRHFA SYANLPGTIT HGMFSSASVR ALIENWAADS VSSRVRGYTC QFVDMVLPNT
1630 1640 1650 1660 1670 1680
ALKTSIQHVG MINGRKLIKF ETRNEDDVVV LTGEAEIEQP VTTFVFTGQG SQEQGMGMDL
1690 1700 1710 1720 1730 1740
YKTSKAAQDV WNRADNHFKD TYGFSILDIV INNPVNLTIH FGGEKGKRIR ENYSAMIFET
1750 1760 1770 1780 1790 1800
IVDGKLKTEK IFKEINEHST SYTFRSEKGL LSATQFTQPA LTLMEKAAFE DLKSKGLIPA
1810 1820 1830 1840 1850 1860
DATFAGHSLG EYAALASLAD VMSIESLVEV VFYRGMTMQV AVPRDELGRS NYGMIAINPG
1870 1880 1890 1900 1910 1920
RVAASFSQEA LQYVVERVGK RTGWLVEIVN YNVENQQYVA AGDLRALDTV TNVLNFIKLQ
1930 1940 1950 1960 1970 1980
KIDIIELQKS LSLEEVEGHL FEIIDEASKK SAVKPRPLKL ERGFACIPLV GISVPFHSTY
1990 2000 2010 2020 2030 2040
LMNGVKPFKS FLKKNIIKEN VKVARLAGKY IPNLTAKPFQ VTKEYFQDVY DLTGSEPIKE
2050
IIDNWEKYEQ S