P06986

PR
Gene name
hisC (b2021, JW2003)
Protein name
Histidinol-phosphate aminotransferase
Names
Imidazole acetol-phosphate transaminase, HPAT, HspAT
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2021
EC number
2.6.1.9: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P06986

Entry ID Method Resolution Chain Position Source
1FG3 X-ray 220 A A 1-356 PDB
1FG7 X-ray 150 A A 1-356 PDB
1GEW X-ray 200 A A 1-356 PDB
1GEX X-ray 220 A A 1-356 PDB
1GEY X-ray 230 A A 1-356 PDB
1IJI X-ray 220 A A 1-356 PDB
AF-P06986-F1 Predicted AlphaFoldDB

No variants for P06986

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P06986

No associated diseases with P06986

2 regional properties for P06986

Type Name Position InterPro Accession
binding_site Aminotransferase, class-II, pyridoxal-phosphate binding site 211 - 220 IPR001917
domain Aminotransferase, class I/classII 46 - 351 IPR004839

Functions

Description
EC Number 2.6.1.9 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
identical protein binding Binding to an identical protein or proteins.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTVTITDLA RENVRNLTPY QSARRLGGNG DVWLNANEYP TAVEFQLTQQ TLNRYPECQP
70 80 90 100 110 120
KAVIENYAQY AGVKPEQVLV SRGADEGIEL LIRAFCEPGK DAILYCPPTY GMYSVSAETI
130 140 150 160 170 180
GVECRTVPTL DNWQLDLQGI SDKLDGVKVV YVCSPNNPTG QLINPQDFRT LLELTRGKAI
190 200 210 220 230 240
VVADEAYIEF CPQASLAGWL AEYPHLAILR TLSKAFALAG LRCGFTLANE EVINLLMKVI
250 260 270 280 290 300
APYPLSTPVA DIAAQALSPQ GIVAMRERVA QIIAEREYLI AALKEIPCVE QVFDSETNYI
310 320 330 340 350
LARFKASSAV FKSLWDQGII LRDQNKQPSL SGCLRITVGT REESQRVIDA LRAEQV