P06972

PR
Gene name
fhuB (b0153, JW0149)
Protein name
Iron(3+)-hydroxamate import system permease protein FhuB
Names
Ferric hydroxamate uptake protein B, Ferrichrome transport system permease protein FhuB, Ferrichrome uptake protein FhuB, Iron(III)-hydroxamate import system permease protein FhuB
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0153
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

297-373 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P06972

Entry ID Method Resolution Chain Position Source
7LB8 EM 340 A B 1-660 PDB
AF-P06972-F1 Predicted AlphaFoldDB

No variants for P06972

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P06972

No associated diseases with P06972

No regional properties for P06972

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P06972

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ATP-binding cassette (ABC) transporter complex A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
iron ion import across plasma membrane The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol.
siderophore-dependent iron import into cell A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKRIALFPA LLLALLVIVA TALTWMNFSQ ALPRSQWAQA AWSPDIDVIE QMIFHYSLLP
70 80 90 100 110 120
RLAISLLVGA GLGLVGVLFQ QVLRNPLAEP TTLGVATGAQ LGITVTTLWA IPGAMASQFA
130 140 150 160 170 180
AQAGACVVGL IVFGVAWGKR LSPVTLILAG LVVSLYCGAI NQLLVIFHHD QLQSMFLWST
190 200 210 220 230 240
GTLTQTDWGG VERLWPQLLG GVMLTLLLLR PLTLMGLDDG VARNLGLALS LARLAALSLA
250 260 270 280 290 300
IVISALLVNA VGIIGFIGLF APLLAKMLGA RRLLPRLMLA SLIGALILWL SDQIILWLTR
310 320 330 340 350 360
VWMEVSTGSV TALIGAPLLL WLLPRLRSIS APDMKVNDRV AAERQHVLAF ALAGGVLLLM
370 380 390 400 410 420
AVVVALSFGR DAHGWTWASG ALLEDLMPWR WPRIMAALFA GVMLAVAGCI IQRLTGNPMA
430 440 450 460 470 480
SPEVLGISSG AAFGVVLMLF LVPGNAFGWL LPAGSLGAAV TLLIIMIAAG RGGFSPHRML
490 500 510 520 530 540
LAGMALSTAF TMLLMMLQAS GDPRMAQVLT WISGSTYNAT DAQVWRTGIV MVILLAITPL
550 560 570 580 590 600
CRRWLTILPL GGDTARAVGM ALTPTRIALL LLAACLTATA TMTIGPLSFV GLMAPHIARM
610 620 630 640 650
MGFRRTMPHI VISALVGGLL LVFADWCGRM VLFPFQIPAG LLSTFIGAPY FIYLLRKQSR