P06909

PR
Gene name
Cfh (Hf1)
Protein name
Complement factor H
Names
Protein beta-1-H
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12628
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

839-917 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P06909

Entry ID Method Resolution Chain Position Source
2YBY X-ray 158 A A 321-444 PDB
AF-P06909-F1 Predicted AlphaFoldDB

65 variants for P06909

Variant ID(s) Position Change Description Diseaes Association Provenance
rs36947627 48 A>V No EVA
rs3388502799 61 T>I No EVA
rs3388502751 68 N>I No EVA
rs3388501688 71 W>R No EVA
rs3388505838 73 A>S No EVA
rs3388500570 99 A>V No EVA
rs3388502580 132 D>E No EVA
rs3388505134 132 D>V No EVA
rs3388503792 139 P>S No EVA
rs3388505074 140 L>I No EVA
rs3388504331 143 V>I No EVA
rs262366520 219 D>E No EVA
rs585323518 221 I>L No EVA
rs578439397 250 V>I No EVA
rs1131891812 264 E>Q No EVA
rs251747452 266 R>T No EVA
rs3388504978 269 P>S No EVA
rs578903941 271 Y>H No EVA
rs107672533 286 S>T No EVA
rs3388505380 290 I>N No EVA
rs584837583 311 P>L No EVA
rs1132372992 356 K>R No EVA
rs241724059 358 D>H No EVA
rs584627175 398 D>E No EVA
rs580617139 404 K>N No EVA
rs586811204 405 V>I No EVA
rs108899218 428 T>I No EVA
rs211940980 465 S>Y No EVA
rs246435726 476 R>K No EVA
rs217096018 504 S>T No EVA
rs582287089 543 E>K No EVA
rs1133250643 631 P>Q No EVA
rs582521379 684 I>V No EVA
rs31728142 703 C>F No EVA
rs31728142 703 C>Y No EVA
rs233759670 721 N>T No EVA
rs3388503778 732 C>Y No EVA
rs3388505902 737 W>* No EVA
rs3388500509 750 E>V No EVA
rs3410573663 751 K>S No EVA
rs3388503408 753 R>G No EVA
rs213551716 777 D>N No EVA
rs3388505605 783 K>N No EVA
rs3390709367 872 T>I No EVA
rs3390709403 873 I>V No EVA
rs245670303 877 S>F No EVA
rs13462834 887 R>K No EVA
rs215178389 892 E>D No EVA
rs1134468386 917 R>G No EVA
rs1133445517 943 P>L No EVA
rs1134715620 944 L>R No EVA
rs32512169 977 I>K No EVA
rs216958260 1020 T>A No EVA
rs3388504965 1063 T>S No EVA
rs3388504305 1068 T>S No EVA
rs36495977 1070 N>D No EVA
rs580904640 1181 S>A No EVA
rs3388500592 1193 K>R No EVA
rs218130190 1211 Y>C No EVA
rs239715054 1211 Y>H No EVA
rs3388502623 1215 D>G No EVA
rs250368000 1215 D>N No EVA
rs1132229590 1223 C>Y No EVA
rs239369781 1227 T>I No EVA
rs226962491 1232 T>S No EVA

No associated diseases with P06909

20 regional properties for P06909

Type Name Position InterPro Accession
domain Sushi/SCR/CCP domain 19 - 82 IPR000436-1
domain Sushi/SCR/CCP domain 83 - 143 IPR000436-2
domain Sushi/SCR/CCP domain 144 - 207 IPR000436-3
domain Sushi/SCR/CCP domain 208 - 264 IPR000436-4
domain Sushi/SCR/CCP domain 265 - 322 IPR000436-5
domain Sushi/SCR/CCP domain 325 - 385 IPR000436-6
domain Sushi/SCR/CCP domain 387 - 444 IPR000436-7
domain Sushi/SCR/CCP domain 446 - 507 IPR000436-8
domain Sushi/SCR/CCP domain 509 - 564 IPR000436-9
domain Sushi/SCR/CCP domain 567 - 624 IPR000436-10
domain Sushi/SCR/CCP domain 627 - 685 IPR000436-11
domain Sushi/SCR/CCP domain 688 - 745 IPR000436-12
domain Sushi/SCR/CCP domain 752 - 802 IPR000436-13
domain Sushi/SCR/CCP domain 806 - 863 IPR000436-14
domain Sushi/SCR/CCP domain 865 - 933 IPR000436-15
domain Sushi/SCR/CCP domain 934 - 991 IPR000436-16
domain Sushi/SCR/CCP domain 992 - 1050 IPR000436-17
domain Sushi/SCR/CCP domain 1051 - 1109 IPR000436-18
domain Sushi/SCR/CCP domain 1112 - 1170 IPR000436-19
domain Sushi/SCR/CCP domain 1172 - 1233 IPR000436-20

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
serine-type endopeptidase complex A protein complex which is capable of serine-type endopeptidase activity.

4 GO annotations of molecular function

Name Definition
complement component C3b binding Binding to a C3b product of the complement cascade.
heparan sulfate proteoglycan binding Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
identical protein binding Binding to an identical protein or proteins.

30 GO annotations of biological process

Name Definition
activation of membrane attack complex The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
complement activation Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
complement activation, alternative pathway Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
glomerulus development The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
mitochondrial DNA metabolic process The chemical reactions and pathways involving mitochondrial DNA.
mitochondrial gene expression The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
monocyte aggregation The adhesion of one monocyte to one or more other monocytes via adhesion molecules.
neuromuscular process Any process pertaining to the functions of the nervous and muscular systems of an organism.
organelle localization Any process in which an organelle is transported to, and/or maintained in, a specific location.
photoreceptor cell differentiation The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.
platelet aggregation The adhesion of one platelet to one or more other platelets via adhesion molecules.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of complement activation Any process that modulates the frequency, rate or extent of complement activation.
regulation of complement activation, alternative pathway Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.
regulation of complement-dependent cytotoxicity Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity.
response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
response to dietary excess The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
retinal pigment epithelium development The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
retinal rod cell development Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.
vascular associated smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLSARIIWL ILWTVCAAED CKGPPPRENS EILSGSWSEQ LYPEGTQATY KCRPGYRTLG
70 80 90 100 110 120
TIVKVCKNGK WVASNPSRIC RKKPCGHPGD TPFGSFRLAV GSQFEFGAKV VYTCDDGYQL
130 140 150 160 170 180
LGEIDYRECG ADGWINDIPL CEVVKCLPVT ELENGRIVSG AAETDQEYYF GQVVRFECNS
190 200 210 220 230 240
GFKIEGHKEI HCSENGLWSN EKPRCVEILC TPPRVENGDG INVKPVYKEN ERYHYKCKHG
250 260 270 280 290 300
YVPKERGDAV CTGSGWSSQP FCEEKRCSPP YILNGIYTPH RIIHRSDDEI RYECNYGFYP
310 320 330 340 350 360
VTGSTVSKCT PTGWIPVPRC TLKPCEFPQF KYGRLYYEES LRPNFPVSIG NKYSYKCDNG
370 380 390 400 410 420
FSPPSGYSWD YLRCTAQGWE PEVPCVRKCV FHYVENGDSA YWEKVYVQGQ SLKVQCYNGY
430 440 450 460 470 480
SLQNGQDTMT CTENGWSPPP KCIRIKTCSA SDIHIDNGFL SESSSIYALN RETSYRCKQG
490 500 510 520 530 540
YVTNTGEISG SITCLQNGWS PQPSCIKSCD MPVFENSITK NTRTWFKLND KLDYECLVGF
550 560 570 580 590 600
ENEYKHTKGS ITCTYYGWSD TPSCYERECS VPTLDRKLVV SPRKEKYRVG DLLEFSCHSG
610 620 630 640 650 660
HRVGPDSVQC YHFGWSPGFP TCKGQVASCA PPLEILNGEI NGAKKVEYSH GEVVKYDCKP
670 680 690 700 710 720
RFLLKGPNKI QCVDGNWTTL PVCIEEERTC GDIPELEHGS AKCSVPPYHH GDSVEFICEE
730 740 750 760 770 780
NFTMIGHGSV SCISGKWTQL PKCVATDQLE KCRVLKSTGI EAIKPKLTEF THNSTMDYKC
790 800 810 820 830 840
RDKQEYERSI CINGKWDPEP NCTSKTSCPP PPQIPNTQVI ETTVKYLDGE KLSVLCQDNY
850 860 870 880 890 900
LTQDSEEMVC KDGRWQSLPR CIEKIPCSQP PTIEHGSINL PRSSEERRDS IESSSHEHGT
910 920 930 940 950 960
TFSYVCDDGF RIPEENRITC YMGKWSTPPR CVGLPCGPPP SIPLGTVSLE LESYQHGEEV
970 980 990 1000 1010 1020
TYHCSTGFGI DGPAFIICEG GKWSDPPKCI KTDCDVLPTV KNAIIRGKSK KSYRTGEQVT
1030 1040 1050 1060 1070 1080
FRCQSPYQMN GSDTVTCVNS RWIGQPVCKD NSCVDPPHVP NATIVTRTKN KYLHGDRVRY
1090 1100 1110 1120 1130 1140
ECNKPLELFG QVEVMCENGI WTEKPKCRDS TGKCGPPPPI DNGDITSLSL PVYEPLSSVE
1150 1160 1170 1180 1190 1200
YQCQKYYLLK GKKTITCRNG KWSEPPTCLH ACVIPENIME SHNIILKWRH TEKIYSHSGE
1210 1220 1230
DIEFGCKYGY YKARDSPPFR TKCINGTINY PTCV