P06653

PR
Gene name
lytA (SP_1937)
Protein name
Autolysin
Names
Cell wall hydrolase, Mucopeptide aminohydrolase, Murein hydrolase, N-acetylmuramoyl-L-alanine amidase
Species
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
KEGG Pathway
spn:SP_1937
EC number
3.5.1.28: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P06653

Entry ID Method Resolution Chain Position Source
1GVM X-ray 280 A A/B/C/D/E/F 188-318 PDB
1H8G X-ray 240 A A/B 224-318 PDB
1HCX X-ray 260 A A/B 192-318 PDB
2BML X-ray 260 A A/B 193-318 PDB
4IVV X-ray 105 A A 1-180 PDB
4X36 X-ray 210 A A 1-318 PDB
5CTV X-ray 105 A A 1-180 PDB
AF-P06653-F1 Predicted AlphaFoldDB

No variants for P06653

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P06653

No associated diseases with P06653

4 regional properties for P06653

Type Name Position InterPro Accession
domain N-acetylmuramoyl-L-alanine amidase domain 10 - 153 IPR002502
repeat Cell wall/choline-binding repeat 196 - 215 IPR018337-1
repeat Cell wall/choline-binding repeat 217 - 237 IPR018337-2
repeat Cell wall/choline-binding repeat 238 - 283 IPR018337-3

Functions

Description
EC Number 3.5.1.28 In linear amides
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
N-acetylmuramoyl-L-alanine amidase activity Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.

4 GO annotations of biological process

Name Definition
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
establishment of competence for transformation The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.
peptidoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEINVSKLRT DLPQVGVQPY RQVHAHSTGN PHSTVQNEAD YHWRKDPELG FFSHIVGNGC
70 80 90 100 110 120
IMQVGPVDNG AWDVGGGWNA ETYAAVELIE SHSTKEEFMT DYRLYIELLR NLADEAGLPK
130 140 150 160 170 180
TLDTGSLAGI KTHEYCTNNQ PNNHSDHVDP YPYLAKWGIS REQFKHDIEN GLTIETGWQK
190 200 210 220 230 240
NDTGYWYVHS DGSYPKDKFE KINGTWYYFD SSGYMLADRW RKHTDGNWYW FDNSGEMATG
250 260 270 280 290 300
WKKIADKWYY FNEEGAMKTG WVKYKDTWYY LDAKEGAMVS NAFIQSADGT GWYYLKPDGT
310
LADKPEFTVE PDGLITVK