P06332

PR
Gene name
Cd4
Protein name
T-cell surface glycoprotein CD4
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12504
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

114-198 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P06332

Entry ID Method Resolution Chain Position Source
AF-P06332-F1 Predicted AlphaFoldDB

34 variants for P06332

Variant ID(s) Position Change Description Diseaes Association Provenance
rs46280311 4 A>G No EVA
rs3388844775 15 L>P No EVA
rs3388862004 48 K>Q No EVA
rs3388860907 52 F>L No EVA
rs3388855228 122 E>Q No EVA
rs258799216 157 T>I No EVA
rs3388850415 161 H>Y No EVA
rs241199810 163 K>R No EVA
rs216696357 165 K>R No EVA
rs3397335066 185 F>S No EVA
rs51521529 196 K>R No EVA
rs217236309 237 W>R No EVA
rs47132330 252 P>S No EVA
rs3388858238 271 D>E No EVA
rs3388863602 279 T>M No EVA
rs3388858331 291 L>R No EVA
rs3388850476 293 F>L No EVA
rs3388850456 296 S>Y No EVA
rs3388858309 325 T>I No EVA
rs3388860946 330 V>M No EVA
rs3388858273 332 G>E No EVA
rs229227834 338 M>T No EVA
rs50728834 341 T>S No EVA
rs3388850430 351 V>D No EVA
rs237953978 357 V>L No EVA
rs262666607 365 T>I No EVA
rs247476370 376 D>E No EVA
rs3388823659 377 K>N No EVA
rs3388854368 395 V>M No EVA
rs248119676 399 C>G No EVA
rs3388855194 402 G>D No EVA
rs3388841897 404 S>T No EVA
rs3388860897 456 L>I No EVA
rs3388854316 458 I>L No EVA

No associated diseases with P06332

10 regional properties for P06332

Type Name Position InterPro Accession
domain Immunoglobulin subtype 27 - 126 IPR003599-1
domain Immunoglobulin subtype 131 - 206 IPR003599-2
domain Immunoglobulin subtype 212 - 317 IPR003599-3
domain Immunoglobulin-like domain 34 - 122 IPR007110
domain Immunoglobulin C2-set 128 - 206 IPR008424-1
domain Immunoglobulin C2-set 317 - 387 IPR008424-2
domain Immunoglobulin V-set domain 37 - 114 IPR013106
domain Immunoglobulin 26 - 126 IPR013151
domain CD4, extracellular 212 - 316 IPR015274
domain T cell CD4 receptor C-terminal region 427 - 452 IPR021963

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

13 GO annotations of molecular function

Name Definition
coreceptor activity Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
identical protein binding Binding to an identical protein or proteins.
immunoglobulin binding Binding to an immunoglobulin.
interleukin-16 binding Binding to interleukin-16.
interleukin-16 receptor activity Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
MHC class II protein binding Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
MHC class II protein complex binding Binding to a class II major histocompatibility complex.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine kinase binding Binding to protein tyrosine kinase.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
zinc ion binding Binding to a zinc ion (Zn).

30 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
cellular response to granulocyte macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
helper T cell enhancement of adaptive immune response Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.
interleukin-15-mediated signaling pathway The series of molecular signals initiated by interleukin-15 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
macrophage differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
maintenance of protein location in cell Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of calcium ion transport into cytosol Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of monocyte differentiation Any process that activates or increases the frequency, rate or extent of monocyte differentiation.
positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of T cell activation Any process that activates or increases the frequency, rate or extent of T cell activation.
positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation.
positive regulation of viral entry into host cell Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell.
regulation of calcium ion transport Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of T cell activation Any process that modulates the frequency, rate or extent of T cell activation.
T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
T cell selection The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCRAISLRRL LLLLLQLSQL LAVTQGKTLV LGKEGESAEL PCESSQKKIT VFTWKFSDQR
70 80 90 100 110 120
KILGQHGKGV LIRGGSPSQF DRFDSKKGAW EKGSFPLIIN KLKMEDSQTY ICELENRKEE
130 140 150 160 170 180
VELWVFKVTF SPGTSLLQGQ SLTLTLDSNS KVSNPLTECK HKKGKVVSGS KVLSMSNLRV
190 200 210 220 230 240
QDSDFWNCTV TLDQKKNWFG MTLSVLGFQS TAITAYKSEG ESAEFSFPLN FAEENGWGEL
250 260 270 280 290 300
MWKAEKDSFF QPWISFSIKN KEVSVQKSTK DLKLQLKETL PLTLKIPQVS LQFAGSGNLT
310 320 330 340 350 360
LTLDKGTLHQ EVNLVVMKVA QLNNTLTCEV MGPTSPKMRL TLKQENQEAR VSEEQKVVQV
370 380 390 400 410 420
VAPETGLWQC LLSEGDKVKM DSRIQVLSRG VNQTVFLACV LGGSFGFLGF LGLCILCCVR
430 440 450
CRHQQRQAAR MSQIKRLLSE KKTCQCPHRM QKSHNLI