AiPD: Autoinhibited Protein Database

Gene name	PTGS1 (COX1)
Protein name	Prostaglandin G/H synthase 1
Names	Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1
Species	Ovis aries (Sheep)
KEGG Pathway	oas:443551
EC number	1.14.99.1: Miscellaneous
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-58 (Predicted disordered autoinhibitory region) PR

1-58 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1CQE	X-ray	310 A	A/B	21-600	PDB
1DIY	X-ray	300 A	A	32-584	PDB
1EBV	X-ray	320 A	A	33-583	PDB
1EQG	X-ray	261 A	A/B	21-600	PDB
1EQH	X-ray	270 A	A/B	21-600	PDB
1FE2	X-ray	300 A	A	25-600	PDB
1HT5	X-ray	275 A	A/B	33-583	PDB
1HT8	X-ray	269 A	A/B	33-583	PDB
1IGX	X-ray	310 A	A	25-600	PDB
1IGZ	X-ray	290 A	A	25-600	PDB
1PGE	X-ray	350 A	A/B	25-600	PDB
1PGF	X-ray	450 A	A/B	25-600	PDB
1PGG	X-ray	450 A	A/B	25-600	PDB
1PRH	X-ray	350 A	A/B	33-586	PDB
1PTH	X-ray	340 A	A/B	25-600	PDB
1Q4G	X-ray	200 A	A/B	32-584	PDB
1U67	X-ray	310 A	A	1-600	PDB
2AYL	X-ray	200 A	A/B	32-584	PDB
2OYE	X-ray	285 A	P	1-600	PDB
2OYU	X-ray	270 A	P	1-600	PDB
3KK6	X-ray	275 A	A/B	32-584	PDB
3N8V	X-ray	305 A	A/B	32-584	PDB
3N8W	X-ray	275 A	A/B	32-584	PDB
3N8X	X-ray	275 A	A/B	32-584	PDB
3N8Y	X-ray	260 A	A/B	32-584	PDB
3N8Z	X-ray	290 A	A/B	32-584	PDB
4O1Z	X-ray	240 A	A/B	32-600	PDB
5U6X	X-ray	293 A	A/B	1-600	PDB
5WBE	X-ray	275 A	A/B	1-600	PDB
7JXT	X-ray	335 A	A/B	32-584	PDB
AF-P05979-F1	Predicted				AlphaFoldDB

Position	Change	Diseaes Association
97	R>H	No
164	D>G	No
456	R>Q	No
520	E>K	No
520	E>Q	No
525	M>I	No

Type	Name	Position	InterPro Accession
domain	EGF-like domain	32 - 70	IPR000742

		Description
EC Number	1.14.99.1	Miscellaneous
Subcellular Localization	Endoplasmic reticulum membrane; Multi-pass membrane protein Microsome membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

Name	Definition
dioxygenase activity	Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding	Binding to a metal ion.
peroxidase activity	Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.
prostaglandin-endoperoxide synthase activity	Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

Name	Definition
cyclooxygenase pathway	The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
prostaglandin biosynthetic process	The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
regulation of blood pressure	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins