P05897

PR
Gene name
gag-pol
Protein name
Gag-Pol polyprotein
Names
Pr160Gag-Pol
Species
Simian immunodeficiency virus (isolate K6W) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P05897

Entry ID Method Resolution Chain Position Source
1C6V X-ray 300 A X 1366-1446 PDB
1ECW X-ray 220 A A 1-135 PDB
1ED1 X-ray 210 A A 1-135 PDB

No variants for P05897

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05897

No associated diseases with P05897

16 regional properties for P05897

Type Name Position InterPro Accession
domain Immunodeficiency lentiviral matrix, N-terminal 2 - 131 IPR000071
domain Reverse transcriptase domain 640 - 830 IPR000477
domain Retroviral nucleocapsid Gag protein p24, N-terminal 146 - 270 IPR000721
domain Integrase, C-terminal, retroviral 1376 - 1423 IPR001037
domain Integrase, catalytic core 1206 - 1357 IPR001584
domain Zinc finger, CCHC-type 391 - 408 IPR001878-1
domain Zinc finger, CCHC-type 413 - 429 IPR001878-2
active_site Aspartic peptidase, active site 519 - 530 IPR001969
domain Peptidase A2A, retrovirus, catalytic 517 - 586 IPR001995
domain Ribonuclease H domain 1029 - 1150 IPR002156
domain Integrase, N-terminal zinc-binding domain 1156 - 1198 IPR003308
domain Reverse transcriptase connection 914 - 1014 IPR010659
domain Reverse transcriptase thumb 837 - 898 IPR010661
domain Retropepsins 503 - 594 IPR018061
domain Retropepsin-like catalytic domain 508 - 588 IPR034170
domain Retroviral nucleocapsid Gag protein p24, C-terminal domain 277 - 350 IPR045345

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • [Matrix protein p17]: Virion
  • Host nucleus
  • Host cytoplasm
  • Host cell membrane ; Lipid-anchor
  • Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome
  • During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host cell plasma membrane The plasma membrane surrounding a host cell.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
viral nucleocapsid The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.

9 GO annotations of molecular function

Name Definition
aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exoribonuclease H activity Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
zinc ion binding Binding to a zinc ion (Zn).

8 GO annotations of biological process

Name Definition
DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
suppression by virus of host gene expression Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses.
viral penetration into host nucleus The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGARNSVLSG KKADELEKIR LRPGGKKKYM LKHVVWAANE LDRFGLAESL LENKEGCQKI
70 80 90 100 110 120
LSVLAPLVPT GSENLKSLYN TVCVIWCIHA EEKVKHTEEA KQIVQRHLVV ETGTAETMPK
130 140 150 160 170 180
TSRPTAPSSG RGGNYPVQQI GGNYVHLPLS PRTLNAWVKL IEEKKFGAEV VPGFQALSEG
190 200 210 220 230 240
CTPYDINQML NCVGDHQAAM QIIRDIINEE AADWDLQHPQ PAPQQGQLRE PSGSDIAGTT
250 260 270 280 290 300
SSVDEQIQWM YRQQNPIPVG NIYRRWIQLG LQKCVRMYNP TNILDVKQGP KEPFQSYVDR
310 320 330 340 350 360
FYKSLRAEQT DAAVKNWMTQ TLLIQNANPD CKLVLKGLGV NPTLEEMLTA CQGVGGPGQK
370 380 390 400 410 420
ARLMAEALKE ALAPVPIPFA AAQKRGPRKP IKCWNCGKEG HSARQCRAPR RQGCWKCGKM
430 440 450 460 470 480
DHVMAKCPDR QAGFFRPWSM GKEAPQFPHG SSASGADANC SPRGPSCGSA KELHAVGQAA
490 500 510 520 530 540
ERKQREALQG GDRGFAAPQF SLWRRPVVTA HIEGQPVEVL LDTGADDSIV TGIELGPHYT
550 560 570 580 590 600
PKIVGGIGGF INTKEYKNVE IEVLGKRIKR TIMTGDTPIN IFGRNLLTAL GMSLNLPIAK
610 620 630 640 650 660
VEPVKVALKP GKVGPKLKQW PLSKEKIVAL REICEKMEKD GQLEEAPPTN PYNTPTFAIK
670 680 690 700 710 720
KKDKNKWRML IHFRELNRVT QELYRSPIRI PHPAGLAKRK RITVLDIGDA YFSIPLDEEF
730 740 750 760 770 780
RQYTAFTLPS VNNAEPGKRY IYKVLPQGWK GSPAIFQYTM RHVLEPFRKA NPDVTLVQYM
790 800 810 820 830 840
DDILIASDRT DLEHDRVVLQ LKELLNSIGF STPEEKFQKD PPFQWMGYEL WPTKWKLQKI
850 860 870 880 890 900
ELPQRETWTV NDIQKLVGVL NWAAQIYPGI KTKHLCRLIR GKMTLTEAVQ WTEMAEAEYE
910 920 930 940 950 960
ENNIILSQEQ EGCYYQEGKP LEATVIKSQD NQWTYKIHQE DKILKVRKFA KIKNTHTNGV
970 980 990 1000 1010 1020
RLLAHVIQKI GKEAIVIVGQ VPKFHLPVER DVWEQWWTDY WQVTWIPEWD FISTPPLVRL
1030 1040 1050 1060 1070 1080
VFNLVKDPIE VEETYYTDGS CNKQSKEGKA GYITDRGKDI VKVLTTTNQQ AELEAIYHGI
1090 1100 1110 1120 1130 1140
EDSGPKRNII VELQVCYGNN NRFPTESESR LVNQIIEEMI KVRVYVAWVP ALEGIGGNQE
1150 1160 1170 1180 1190 1200
IGPLVSQGFR QVLFLEKIEP AQEEHDKYHS NVKELVFKFG LPRIVARQIV DTCDKCHQKG
1210 1220 1230 1240 1250 1260
EAIHGQVNSD LGTWQMDCTH LEGKIVIVAV HVASGFIEAE VIPQETGRQH YFLLKLAGRW
1270 1280 1290 1300 1310 1320
PYLHIYTHSN GANFASQEVK MVTWWAGIEA HLWVPYNPQS QGVVEAMNHH LKNQIDRIRE
1330 1340 1350 1360 1370 1380
QANSVETIVL MAVHCMNFKR RGGIGDMTPA ERLINMITTE QEIQFQQSKN SKFKNFRVYY
1390 1400 1410 1420 1430 1440
REGRDQLWKG PGELLWKGEG AVILKVGTDI KVVPRRKAKI IKDYGGGKEV DSSSHMEDTG
EAREVA