P05620

PR
Gene name
TLF1
Protein name
Thrombin-like enzyme flavoxobin
Names
SVTLE, Fibrinogen-clotting enzyme, Habutobin, Snake venom serine protease 1, SVSP
Species
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
KEGG Pathway
EC number
3.4.21.74: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

95-165 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P05620

Entry ID Method Resolution Chain Position Source
AF-P05620-F1 Predicted AlphaFoldDB

No variants for P05620

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05620

No associated diseases with P05620

2 regional properties for P05620

Type Name Position InterPro Accession
domain Serine proteases, trypsin domain 24 - 251 IPR001254
active_site Serine proteases, trypsin family, histidine active site 63 - 68 IPR018114

Functions

Description
EC Number 3.4.21.74 Serine endopeptidases
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

2 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLIRVLANL LILQLSYAQK SSELVIGGDE CNINEHPFLV ALYDAWSGRF LCGGTLINPE
70 80 90 100 110 120
WVLTAAHCDS KNFKMKLGAH SKKVLNEDEQ IRNPKEKFIC PNKKNDEVLD KDIMLIKLDS
130 140 150 160 170 180
PVSYSEHIAP LSLPSSPPSV GSVCRIMGWG SITPVEETFP DVPHCANINL LDDVECKPGY
190 200 210 220 230 240
PELLPEYRTL CAGVLQGGID TCGFDSGTPL ICNGQFQGIV SYGGHPCGQS RKPGIYTKVF
250
DYNAWIQSII AGNTAATCLP