AiPD: Autoinhibited Protein Database

Gene name	CHO2
Protein name	Phosphatidylethanolamine N-methyltransferase
Names	PE methyltransferase, PEAMT, PEMT, Choline-requiring protein 2
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YGR157W
EC number	2.1.1.17: Methyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-57 (Predicted disordered autoinhibitory region) PR

1-57 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P05374-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s07-802517	25	E>K	No	SGRP
s07-802629	62	A>V	No	SGRP
s07-802837	131	Q>H	No	SGRP
s07-802881	146	F>S	No	SGRP
s07-802891	149	K>N	No	SGRP
s07-802909	155	R>S	No	SGRP
s07-803222	260	I>V	No	SGRP
s07-803316	291	K>R	No	SGRP
s07-803412	323	T>I	No	SGRP
s07-803469	342	Y>C	No	SGRP
s07-803514	357	N>S	No	SGRP
s07-803579	379	T>A	No	SGRP
s07-803592	383	A>V	No	SGRP
s07-803612	390	Y>H	No	SGRP
s07-803676	411	Y>C	No	SGRP
s07-803751	436	Q>L	No	SGRP
s07-803807	455	H>Y	No	SGRP
s07-803961	506	S>N	No	SGRP
s07-804089	549	I>V	No	SGRP
s07-804383	647	V>I	No	SGRP
s07-804434	664	V>I	No	SGRP
s07-804576	711	G>D	No	SGRP
s07-804821	793	E>K	No	SGRP
s07-805001	853	V>I	No	SGRP

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P05374

		Description
EC Number	2.1.1.17	Methyltransferases
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
phosphatidylethanolamine N-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.

Name	Definition
methylation	The process in which a methyl group is covalently attached to a molecule.
phosphatidylcholine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins