P05335

PR
Gene name
POX4
Protein name
Acyl-coenzyme A oxidase 4
Names
AOX 4, Acyl-CoA oxidase 4
Species
Candida maltosa (Yeast)
KEGG Pathway
EC number
1.3.3.6: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P05335

Entry ID Method Resolution Chain Position Source
AF-P05335-F1 Predicted AlphaFoldDB

No variants for P05335

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05335

No associated diseases with P05335

4 regional properties for P05335

Type Name Position InterPro Accession
domain Acyl-CoA oxidase, C-terminal 515 - 686 IPR002655
domain Acyl-CoA oxidase/dehydrogenase, middle domain 154 - 263 IPR006091
domain Acyl-CoA dehydrogenase/oxidase C-terminal 375 - 468 IPR009075
domain Acyl-coenzyme A oxidase, N-terminal 33 - 140 IPR029320

Functions

Description
EC Number 1.3.3.6 With oxygen as acceptor
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

1 GO annotations of biological process

Name Definition
fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTFTKKNVSV SQGPDPRTSI QTERANSKFD PVTMNYFLEG SKERSELMKS LAQQIERDPI
70 80 90 100 110 120
LFTDGSYYDL TKDQQRELTV LKINRLSRYR EGDSVDTFNK RLSIMGVVDP QVATRIGVNL
130 140 150 160 170 180
GLFLSCISGN GTAEQFKYWA IDKGTHNIQG LYGCFGMTEL GHGSNVAGVE TTATFDKETD
190 200 210 220 230 240
EFVINTPHIG ATKWWIGGAA HSATHCSVYA RLVVDGKDYG VKTFVVPLRD SNHDLMPGVT
250 260 270 280 290 300
VGDIGAKMGR DGIDNGWIQF SNVRIPRFFM LQKFCKVSAE GEVVLPPLEQ LSYSALLGGR
310 320 330 340 350 360
VMMVLDSYRM LARVSTIALR YAIGRRQFKG DNVDQNDPNA LETQLIDYPL HQKRLFPYLA
370 380 390 400 410 420
AAYVVSTGAL KVEHTIQSTL ATLDAAVENN DTTAIFKSID DMKSLFIDSG SLKATTTWLA
430 440 450 460 470 480
AEAIDQCRQA CGGHGYSSYN GFAKAFNDWV VQCTWEGDNN VLSLSVGKPI IKQIIGIEDN
490 500 510 520 530 540
GKTVRGSTAF LNQVKDFTGS NASKVVLNNT SDLNDINKVI KSIEVAIIRL AHEAAISVRK
550 560 570 580 590 600
ESLDFAGAEL VQISKLKAHH YLLTEFVKRV GEFEHKELVP FLNTIGRLYS ATVVLDKFAG
610 620 630 640 650 660
VFLTFNVASP QAITDLASTQ IPKLCAEVRP NVVAYTDSFQ QSDMVINSAI GKYDGDVYEN
670 680 690 700
YFDLVKQLNP PKNTKAPYTA ALEGMLNRPS LEARERYEKS DETAAILSK