P05327

PR
Gene name
phr (phrA, syc1392_c)
Protein name
Deoxyribodipyrimidine photo-lyase
Names
DNA photolyase, Photoreactivating enzyme
Species
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
KEGG Pathway
syc:syc1392_c
EC number
4.1.99.3: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

129-204 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P05327

Entry ID Method Resolution Chain Position Source
1OWL X-ray 180 A A 1-484 PDB
1OWM X-ray 230 A A 1-484 PDB
1OWN X-ray 230 A A 1-484 PDB
1OWO X-ray 230 A A 1-484 PDB
1OWP X-ray 230 A A 1-484 PDB
1QNF X-ray 180 A A 1-484 PDB
1TEZ X-ray 180 A A/B/C/D 2-475 PDB
AF-P05327-F1 Predicted AlphaFoldDB

No variants for P05327

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05327

No associated diseases with P05327

3 regional properties for P05327

Type Name Position InterPro Accession
domain Cryptochrome/DNA photolyase, FAD-binding domain 280 - 469 IPR005101
domain DNA photolyase, N-terminal 3 - 166 IPR006050
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 329 - 341 IPR018394

Functions

Description
EC Number 4.1.99.3 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
deoxyribodipyrimidine photo-lyase activity Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAPILFWHR RDLRLSDNIG LAAARAQSAQ LIGLFCLDPQ ILQSADMAPA RVAYLQGCLQ
70 80 90 100 110 120
ELQQRYQQAG SRLLLLQGDP QHLIPQLAQQ LQAEAVYWNQ DIEPYGRDRD GQVAAALKTA
130 140 150 160 170 180
GIRAVQLWDQ LLHSPDQILS GSGNPYSVYG PFWKNWQAQP KPTPVATPTE LVDLSPEQLT
190 200 210 220 230 240
AIAPLLLSEL PTLKQLGFDW DGGFPVEPGE TAAIARLQEF CDRAIADYDP QRNFPAEAGT
250 260 270 280 290 300
SGLSPALKFG AIGIRQAWRA ASAAHALSRS DEARNSIRVW QQELAWREFY QHALYHFPSL
310 320 330 340 350 360
ADGPYRSLWQ QFPWENREAL FTAWTQAQTG YPIVDAAMRQ LTETGWMHNR CWMIVASFLT
370 380 390 400 410 420
KDLIIDWRRG EQFFMQHLVD GDLAANNGGW QWSASSGMDP KPLRIFNPAS QAKKFDATAT
430 440 450 460 470 480
YIKRWLPELR HVHPKDLISG EITPIGRRGY PAPIVNHNLR QKQFKALYNQ LKAAIAEPEA
EPDS