P05176

PR
Gene name
CYP1A1
Protein name
Cytochrome P450 1A1
Names
CYPIA1, Cytochrome P-450 PHPAH1, Cytochrome P450 isozyme 6, Cytochrome P450 LM6, Cytochrome P450-C, Cytochrome P450-P1, Hydroperoxy icosatetraenoate dehydratase
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100328613
EC number
1.14.14.1: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

119-199 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P05176

Entry ID Method Resolution Chain Position Source
AF-P05176-F1 Predicted AlphaFoldDB

No variants for P05176

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05176

No associated diseases with P05176

1 regional properties for P05176

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 454 - 463 IPR017972

Functions

Description
EC Number 1.14.14.1 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Mitochondrion inner membrane ; Peripheral membrane protein
  • Microsome membrane ; Peripheral membrane protein
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

12 GO annotations of molecular function

Name Definition
arachidonic acid monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.
aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
estrogen 16-alpha-hydroxylase activity Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O.
estrogen 2-hydroxylase activity Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
hydroperoxy icosatetraenoate dehydratase activity A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O.
iron ion binding Binding to an iron (Fe) ion.
long-chain fatty acid omega-1 hydroxylase activity Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized
long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized
vitamin D 24-hydroxylase activity Catalysis of the hydroxylation of C-24 of any form of vitamin D.

12 GO annotations of biological process

Name Definition
amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular response to organic cyclic compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
hydrogen peroxide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
lipid hydroxylation The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
long-chain fatty acid metabolic process The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
retinol metabolic process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVSDFGLPTF ISATELLLAS AVFCLVFWVA GASKPRVPKG LKRLPGPWGW PLLGHVLTLG
70 80 90 100 110 120
KNPHVALARL SRRYGDVFQI RLGSTPVVVL SGLDTIKQAL VRQGDDFKGR PDLYSFSFVT
130 140 150 160 170 180
KGQSMIFGSD SGPVWAARRR LAQNALNSFS VASDPASSSS CYLEEHVSQE AENLISKFQE
190 200 210 220 230 240
LMAAVGHFDP YRYVVMSVAN VICAMCFGRR YDHDDQELLS LVNLNDEFGK VAASGSPADF
250 260 270 280 290 300
FLILRYLPNP ALDTFKDLNE RFYSFTQERV KEHCRSFEKG HIRDITDSLI KHYRVDRLDE
310 320 330 340 350 360
NANVQVSDEK TVGIVLDLFG AGFDTVTTAI SWSLMYLVTK PRIQRKIQEE LDAVVGRARR
370 380 390 400 410 420
PRFSDRPQLP YLEAVIMETF RHTSFLPFTI PHSTTRDTSL GGFYIPKGRC VFVNQWQNNH
430 440 450 460 470 480
DPELWGDPEA FRPERFLTPS GAVDKALTEK VLLFGLGKRK CIGETIGRLE VFLFLATLLQ
490 500 510
QVEFSVSPGT TVDMTPIYGL TMKHARCEHF QAKLRFEA