P05025

PR
Gene name
Protein name
Sodium/potassium-transporting ATPase subunit alpha
Names
Na(+)/K(+) ATPase alpha subunit, Sodium pump subunit alpha
Species
Tetronarce californica (Pacific electric ray) (Torpedo californica)
KEGG Pathway
EC number
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P05025

Entry ID Method Resolution Chain Position Source
AF-P05025-F1 Predicted AlphaFoldDB

No variants for P05025

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P05025

No associated diseases with P05025

1 regional properties for P05025

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 98 - 548 IPR017452

Functions

Description
EC Number 7.2.2.13 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding Binding to a metal ion.
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKGAASEKY QPAATSENAK NSKKSKSKTT DLDELKKEVS LDDHKLNLDE LHQKYGTDLT
70 80 90 100 110 120
QGLTPARAKE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF SILLWTGAIL CFLAYGIQVA
130 140 150 160 170 180
TVDNPANDNL YLGVVLSTVV IITGCFSYYQ EAKSSKIMDS FKNMVPQQAL VIRDGEKSSI
190 200 210 220 230 240
NAEQVVVGDL VEVKGGDRIP ADLRIISACS CKVDNSSLTG ESEPQSRSPE YSSENPLETK
250 260 270 280 290 300
NIAFFSTNCV EGTARGIVIN IGDHTVMGRI ATLASGLEVG QTPIAAEIEH FIHIITGVAV
310 320 330 340 350 360
FLGVSFFILS LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
370 380 390 400 410 420
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGIS FDKTSLSWNA
430 440 450 460 470 480
LSRIAALCNR AVFQAGQDSV PILKRSVAGD ASESALLKCI ELCCGSVSQM RDRNPKIVEI
490 500 510 520 530 540
PFNSTNKYQL SIHENDKADS RYLLVMKGAP ERILDRCSTI LLNGEDKPLN EEMKEAFQNA
550 560 570 580 590 600
YLELGGLGER VLGFCHLKLS TSKFPEGYPF DVEEPNFPIT DLCFVGLMSM IDPPRAAVPD
610 620 630 640 650 660
AVGKCRSAGI KVIMVTGDHP ITAKAIAKGV GIISEGNETV EDIAARLNIP VNQVNPRDAK
670 680 690 700 710 720
ACVVHGTDLK DLSHENLDDI LHYHTEIVFA RTSPQQKLII VEGCQRQGAI VAVTGDGVND
730 740 750 760 770 780
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN LKKSIAYTLT
790 800 810 820 830 840
SNIPEITPFL VFIIANVPLP LGTVTILCID LGTDMVPAIS LAYERAESDI MKRQPRNPKT
850 860 870 880 890 900
DKLVNERLIS MAYGQIGMIQ ALGGFFSYFV ILAENGFLPI DLIGIREKWD ELWTQDLEDS
910 920 930 940 950 960
YGQQWTYEQR KIVEYTCHTS FFVSIVIVQW ADLIICKTRR NSIFQQGMKN KILIFGLFEE
970 980 990 1000 1010 1020
TALAAFLSYT PGTDIALRMY PLKPSWWFCA FPYSLIIFLY DEARRFILRR NPGGWVEQET
YY