P04594

PR
Gene name
gag
Protein name
Gag polyprotein
Names
Pr55Gag
Species
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

429-505 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P04594

Entry ID Method Resolution Chain Position Source

No variants for P04594

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04594

No associated diseases with P04594

5 regional properties for P04594

Type Name Position InterPro Accession
domain Immunodeficiency lentiviral matrix, N-terminal 2 - 138 IPR000071
domain Zinc finger, CCHC-type 396 - 413 IPR001878-1
domain Zinc finger, CCHC-type 418 - 434 IPR001878-2
domain Gag protein p6 455 - 491 IPR014817
domain Retroviral nucleocapsid Gag protein p24, C-terminal domain 283 - 355 IPR045345

Functions

Description
EC Number
Subcellular Localization
  • [Gag polyprotein]: Host cell membrane ; Lipid-anchor
  • Host endosome, host multivesicular body
  • These locations are probably linked to virus assembly sites
  • The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host cell plasma membrane The plasma membrane surrounding a host cell.
host multivesicular body A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
viral nucleocapsid The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.
virion membrane The lipid bilayer surrounding a virion.

3 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
viral budding via host ESCRT complex Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGARASVLSG GKLDAWEKIR LRPGGKKKYR LKHLVWASRE LERFALNPGL LETGEGCQQI
70 80 90 100 110 120
MEQLQSTLKT GSEEIKSLYN TVATLYCVHQ RIDVKDTKEA LDKIEEIQNK SRQKTQQAAA
130 140 150 160 170 180
AQQAAAATKN SSSVSQNYPI VQNAQGQMIH QAISPRTLNA WVKVIEEKAF SPEVIPMFSA
190 200 210 220 230 240
LSEGATPQDL NMMLNIVGGH QAAMQMLKDT INEEAADWDR VHPVHAGPIP PGQMREPRGS
250 260 270 280 290 300
DIAGTTSTLQ EQIGWMTSNP PIPVGDIYKR WIILGLNKIV RMYSPVSILD IRQGPKEPFR
310 320 330 340 350 360
DYVDRFFKTL RAEQATQEVK NWMTETLLVQ NANPDCKTIL KALGPGATLE EMMTACQGVG
370 380 390 400 410 420
GPSHKARVLA EAMSQATNST AAIMMQRGNF KGQKRIKCFN CGKEGHLARN CRAPRKKGCW
430 440 450 460 470 480
KCGKEGHQMK DCTERQANFL GKIWPSHKGR PGNFLQSRPE PTAPPAESFG FGEEIKPSQK
490 500
QEQKDKELYP LASLKSLFGN DQLSQ