P04419

PR
Gene name
col (ceaB)
Protein name
Colicin-E2
Names
Species
Escherichia coli
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P04419

Entry ID Method Resolution Chain Position Source
2YSU X-ray 350 A B 313-447 PDB
3U43 X-ray 172 A B 449-581 PDB
AF-P04419-F1 Predicted AlphaFoldDB

No variants for P04419

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04419

No associated diseases with P04419

3 regional properties for P04419

Type Name Position InterPro Accession
domain HNH nuclease 519 - 575 IPR003615
domain Pyosin/cloacin translocation domain 30 - 311 IPR016128
domain Colicin, receptor domain 314 - 446 IPR024566

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extrachromosomal circular DNA Circular DNA structures that are not part of a chromosome.

2 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
cytolysis The rupture of cell membranes and the loss of cytoplasm.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGGDGRGHN TGAHSTSGNI NGGPTGLGVG GGASDGSGWS SENNPWGGGS GSGIHWGGGS
70 80 90 100 110 120
GHGNGGGNGN SGGGSGTGGN LSAVAAPVAF GFPALSTPGA GGLAVSISAG ALSAAIADIM
130 140 150 160 170 180
AALKGPFKFG LWGVALYGVL PSQIAKDDPN MMSKIVTSLP ADDITESPVS SLPLDKATVN
190 200 210 220 230 240
VNVRVVDDVK DERQNISVVS GVPMSVPVVD AKPTERPGVF TASIPGAPVL NISVNNSTPE
250 260 270 280 290 300
VQTLSPGVTN NTDKDVRPAG FTQGGNTRDA VIRFPKDSGH NAVYVSVSDV LSPDQVKQRQ
310 320 330 340 350 360
DEENRRQQEW DATHPVEAAE RNYERARAEL NQANEDVARN QERQAKAVQV YNSRKSELDA
370 380 390 400 410 420
ANKTLADAIA EIKQFNRFAH DPMAGGHRMW QMAGLKAQRA QTDVNNKQAA FDAAAKEKSD
430 440 450 460 470 480
ADAALSAAQE RRKQKENKEK DAKDKLDKES KRNKPGKATG KGKPVGDKWL DDAGKDSGAP
490 500 510 520 530 540
IPDRIADKLR DKEFKNFDDF RKKFWEEVSK DPDLSKQFKG SNKTNIQKGK APFARKKDQV
550 560 570 580
GGRERFELHH DKPISQDGGV YDMNNIRVTT PKRHIDIHRG K