P04415

PR
Gene name
43
Protein name
DNA-directed DNA polymerase
Names
Gene product 43, Gp43
Species
Enterobacteria phage T4 (Bacteriophage T4)
KEGG Pathway
vg:1258685
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P04415

Entry ID Method Resolution Chain Position Source
1NOY X-ray 220 A A/B 1-388 PDB
1NOZ X-ray 220 A A/B 1-388 PDB

No variants for P04415

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04415

No associated diseases with P04415

3 regional properties for P04415

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 162 - 290 IPR006133
domain DNA-directed DNA polymerase, family B, multifunctional domain 366 - 772 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 616 - 624 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

2 GO annotations of biological process

Name Definition
bidirectional double-stranded viral DNA replication A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKEFYISIET VGNNIVERYI DENGKERTRE VEYLPTMFRH CKEESKYKDI YGKNCAPQKF
70 80 90 100 110 120
PSMKDARDWM KRMEDIGLEA LGMNDFKLAY ISDTYGSEIV YDRKFVRVAN CDIEVTGDKF
130 140 150 160 170 180
PDPMKAEYEI DAITHYDSID DRFYVFDLLN SMYGSVSKWD AKLAAKLDCE GGDEVPQEIL
190 200 210 220 230 240
DRVIYMPFDN ERDMLMEYIN LWEQKRPAIF TGWNIEGFDV PYIMNRVKMI LGERSMKRFS
250 260 270 280 290 300
PIGRVKSKLI QNMYGSKEIY SIDGVSILDY LDLYKKFAFT NLPSFSLESV AQHETKKGKL
310 320 330 340 350 360
PYDGPINKLR ETNHQRYISY NIIDVESVQA IDKIRGFIDL VLSMSYYAKM PFSGVMSPIK
370 380 390 400 410 420
TWDAIIFNSL KGEHKVIPQQ GSHVKQSFPG AFVFEPKPIA RRYIMSFDLT SLYPSIIRQV
430 440 450 460 470 480
NISPETIRGQ FKVHPIHEYI AGTAPKPSDE YSCSPNGWMY DKHQEGIIPK EIAKVFFQRK
490 500 510 520 530 540
DWKKKMFAEE MNAEAIKKII MKGAGSCSTK PEVERYVKFS DDFLNELSNY TESVLNSLIE
550 560 570 580 590 600
ECEKAATLAN TNQLNRKILI NSLYGALGNI HFRYYDLRNA TAITIFGQVG IQWIARKINE
610 620 630 640 650 660
YLNKVCGTND EDFIAAGDTD SVYVCVDKVI EKVGLDRFKE QNDLVEFMNQ FGKKKMEPMI
670 680 690 700 710 720
DVAYRELCDY MNNREHLMHM DREAISCPPL GSKGVGGFWK AKKRYALNVY DMEDKRFAEP
730 740 750 760 770 780
HLKIMGMETQ QSSTPKAVQE ALEESIRRIL QEGEESVQEY YKNFEKEYRQ LDYKVIAEVK
790 800 810 820 830 840
TANDIAKYDD KGWPGFKCPF HIRGVLTYRR AVSGLGVAPI LDGNKVMVLP LREGNPFGDK
850 860 870 880 890
CIAWPSGTEL PKEIRSDVLS WIDHSTLFQK SFVKPLAGMC ESAGMDYEEK ASLDFLFG