P04146

PR
Gene name
GIP (COPIA)
Protein name
Copia protein
Names
Gag-int-pol protein
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-302 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P04146

Entry ID Method Resolution Chain Position Source
AF-P04146-F1 Predicted AlphaFoldDB

2 variants for P04146

Variant ID(s) Position Change Description Diseaes Association Provenance
1265 S>VQQGIYSKCLILISFVGIQRDRTQ variant copia-related [UniProt] No
1289 V>del variant copia-related [UniProt] No

No associated diseases with P04146

4 regional properties for P04146

Type Name Position InterPro Accession
domain Integrase, catalytic core 476 - 644 IPR001584
domain Zinc finger, CCHC-type 231 - 247 IPR001878
domain Reverse transcriptase, RNA-dependent DNA polymerase 920 - 1162 IPR013103
domain GAG-pre-integrase domain 404 - 463 IPR025724

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA polymerase complex A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.

5 GO annotations of molecular function

Name Definition
aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleic acid binding Binding to a nucleic acid.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKAKRNIKP FDGEKYAIWK FRIRALLAEQ DVLKVVDGLM PNEVDDSWKK AERCAKSTII
70 80 90 100 110 120
EYLSDSFLNF ATSDITARQI LENLDAVYER KSLASQLALR KRLLSLKLSS EMSLLSHFHI
130 140 150 160 170 180
FDELISELLA AGAKIEEMDK ISHLLITLPS CYDGIITAIE TLSEENLTLA FVKNRLLDQE
190 200 210 220 230 240
IKIKNDHNDT SKKVMNAIVH NNNNTYKNNL FKNRVTKPKK IFKGNSKYKV KCHHCGREGH
250 260 270 280 290 300
IKKDCFHYKR ILNNKNKENE KQVQTATSHG IAFMVKEVNN TSVMDNCGFV LDSGASDHLI
310 320 330 340 350 360
NDESLYTDSV EVVPPLKIAV AKQGEFIYAT KRGIVRLRND HEITLEDVLF CKEAAGNLMS
370 380 390 400 410 420
VKRLQEAGMS IEFDKSGVTI SKNGLMVVKN SGMLNNVPVI NFQAYSINAK HKNNFRLWHE
430 440 450 460 470 480
RFGHISDGKL LEIKRKNMFS DQSLLNNLEL SCEICEPCLN GKQARLPFKQ LKDKTHIKRP
490 500 510 520 530 540
LFVVHSDVCG PITPVTLDDK NYFVIFVDQF THYCVTYLIK YKSDVFSMFQ DFVAKSEAHF
550 560 570 580 590 600
NLKVVYLYID NGREYLSNEM RQFCVKKGIS YHLTVPHTPQ LNGVSERMIR TITEKARTMV
610 620 630 640 650 660
SGAKLDKSFW GEAVLTATYL INRIPSRALV DSSKTPYEMW HNKKPYLKHL RVFGATVYVH
670 680 690 700 710 720
IKNKQGKFDD KSFKSIFVGY EPNGFKLWDA VNEKFIVARD VVVDETNMVN SRAVKFETVF
730 740 750 760 770 780
LKDSKESENK NFPNDSRKII QTEFPNESKE CDNIQFLKDS KESENKNFPN DSRKIIQTEF
790 800 810 820 830 840
PNESKECDNI QFLKDSKESN KYFLNESKKR KRDDHLNESK GSGNPNESRE SETAEHLKEI
850 860 870 880 890 900
GIDNPTKNDG IEIINRRSER LKTKPQISYN EEDNSLNKVV LNAHTIFNDV PNSFDEIQYR
910 920 930 940 950 960
DDKSSWEEAI NTELNAHKIN NTWTITKRPE NKNIVDSRWV FSVKYNELGN PIRYKARLVA
970 980 990 1000 1010 1020
RGFTQKYQID YEETFAPVAR ISSFRFILSL VIQYNLKVHQ MDVKTAFLNG TLKEEIYMRL
1030 1040 1050 1060 1070 1080
PQGISCNSDN VCKLNKAIYG LKQAARCWFE VFEQALKECE FVNSSVDRCI YILDKGNINE
1090 1100 1110 1120 1130 1140
NIYVLLYVDD VVIATGDMTR MNNFKRYLME KFRMTDLNEI KHFIGIRIEM QEDKIYLSQS
1150 1160 1170 1180 1190 1200
AYVKKILSKF NMENCNAVST PLPSKINYEL LNSDEDCNTP CRSLIGCLMY IMLCTRPDLT
1210 1220 1230 1240 1250 1260
TAVNILSRYS SKNNSELWQN LKRVLRYLKG TIDMKLIFKK NLAFENKIIG YVDSDWAGSE
1270 1280 1290 1300 1310 1320
IDRKSTTGYL FKMFDFNLIC WNTKRQNSVA ASSTEAEYMA LFEAVREALW LKFLLTSINI
1330 1340 1350 1360 1370 1380
KLENPIKIYE DNQGCISIAN NPSCHKRAKH IDIKYHFARE QVQNNVICLE YIPTENQLAD
1390 1400
IFTKPLPAAR FVELRDKLGL LQDDQSNAE