P04133

PR
Gene name
L3
Protein name
Hexon protein
Names
CP-H, Protein II
Species
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for P04133

Entry ID Method Resolution Chain Position Source
1P30 X-ray 250 A A 2-952 PDB
3TG7 X-ray 157 A A 2-952 PDB
4V4U EM 1000 A F/G/H/I/J/K/L/M/N/O/P/Q 2-952 PDB
5LDN X-ray 270 A PDB
5OGI X-ray 280 A A 1-952 PDB
6B1T EM 320 A A/B/C/D/E/F/G/H/I/J/K/L 1-952 PDB
6CGV X-ray 380 A A/B/C/D/E/F/G/H/I/J/K/L 4-952 PDB
6EQC EM 740 A A/B/C 1-952 PDB
7S78 EM 372 A A/B/C/D/E/F/G/H/I/J/K/L 1-952 PDB
8Q7C EM 290 A A/B/C 1-952 PDB

No variants for P04133

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04133

No associated diseases with P04133

2 regional properties for P04133

Type Name Position InterPro Accession
domain Adenovirus Pll, hexon, N-terminal 8 - 635 IPR016107
domain Adenovirus Pll, hexon, C-terminal 636 - 858 IPR016108

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host nucleus
  • Forms the capsid icosahedric shell
  • Present in 720 copies per virion, assembled in 240 trimers
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
T=25 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres.
viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

2 GO annotations of biological process

Name Definition
microtubule-dependent intracellular transport of viral material towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATPSMMPQW SYMHISGQDA SEYLSPGLVQ FARATETYFS LNNKFRNPTV APTHDVTTDR
70 80 90 100 110 120
SQRLTLRFIP VDREDTAYSY KARFTLAVGD NRVLDMASTY FDIRGVLDRG PTFKPYSGTA
130 140 150 160 170 180
YNALAPKGAP NPCEWDEAAT ALEINLEEED DDNEDEVDEQ AEQQKTHVFG QAPYSGINIT
190 200 210 220 230 240
KEGIQIGVEG QTPKYADKTF QPEPQIGESQ WYETEINHAA GRVLKKTTPM KPCYGSYAKP
250 260 270 280 290 300
TNENGGQGIL VKQQNGKLES QVEMQFFSTT EATAGNGDNL TPKVVLYSED VDIETPDTHI
310 320 330 340 350 360
SYMPTIKEGN SRELMGQQSM PNRPNYIAFR DNFIGLMYYN STGNMGVLAG QASQLNAVVD
370 380 390 400 410 420
LQDRNTELSY QLLLDSIGDR TRYFSMWNQA VDSYDPDVRI IENHGTEDEL PNYCFPLGGV
430 440 450 460 470 480
INTETLTKVK PKTGQENGWE KDATEFSDKN EIRVGNNFAM EINLNANLWR NFLYSNIALY
490 500 510 520 530 540
LPDKLKYSPS NVKISDNPNT YDYMNKRVVA PGLVDCYINL GARWSLDYMD NVNPFNHHRN
550 560 570 580 590 600
AGLRYRSMLL GNGRYVPFHI QVPQKFFAIK NLLLLPGSYT YEWNFRKDVN MVLQSSLGND
610 620 630 640 650 660
LRVDGASIKF DSICLYATFF PMAHNTASTL EAMLRNDTND QSFNDYLSAA NMLYPIPANA
670 680 690 700 710 720
TNVPISIPSR NWAAFRGWAF TRLKTKETPS LGSGYDPYYT YSGSIPYLDG TFYLNHTFKK
730 740 750 760 770 780
VAITFDSSVS WPGNDRLLTP NEFEIKRSVD GEGYNVAQCN MTKDWFLVQM LANYNIGYQG
790 800 810 820 830 840
FYIPESYKDR MYSFFRNFQP MSRQVVDDTK YKDYQQVGIL HQHNNSGFVG YLAPTMREGQ
850 860 870 880 890 900
AYPANFPYPL IGKTAVDSIT QKKFLCDRTL WRIPFSSNFM SMGALTDLGQ NLLYANSAHA
910 920 930 940 950
LDMTFEVDPM DEPTLLYVLF EVFDVVRVHR PHRGVIETVY LRTPFSAGNA TT