P04105

PR
Gene name
ALTBN (ALTB1)
Protein name
Tubulin alpha-1B chain
Names
Tubulin alpha-N chain
Species
Physarum polycephalum (Slime mold)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P04105

Entry ID Method Resolution Chain Position Source
AF-P04105-F1 Predicted AlphaFoldDB

No variants for P04105

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04105

No associated diseases with P04105

3 regional properties for P04105

Type Name Position InterPro Accession
domain SH3 domain 609 - 682 IPR001452
domain BAR domain 12 - 240 IPR004148
domain Amphiphysin I, SH3 domain 610 - 681 IPR035470

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, spindle
  • Nucleus
  • Mitosis in the slime mold Plasmodium differs from the process in many eukaryotes
  • The tubulin chains must be transported to the nuclei for intranuclear assembly of the spindle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

1 GO annotations of biological process

Name Definition
microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MREIISIHIG QAGAQVGNAC WELYCLEHGI NPDGQMPSDK SVGGGDDAFN TFFSETSSGK
70 80 90 100 110 120
HVPRAIYLDL EPTVIDEIRT GTYRQLFHPE QLITGKEDAA NNYARGHYTV GKEIVDLCLD
130 140 150 160 170 180
RVRKLADQCS GLQGFLVFHS VGGGTGSGFG SLLLERLSVD YGKKSKLDFC VYPSPQVSTA
190 200 210 220 230 240
VVEPYNSVLS THGLLEHTDV AFMLDNEAIY DLCKKSLDID RPSYANLNRL VAQVISSLTT
250 260 270 280 290 300
SLRFDGALNV DINEFQTNLV PYPRIHFMLA SYAPVISAEK AFHEQLSVAE LTNTVFEPSS
310 320 330 340 350 360
MMAKCDPRHG KYMACCLMYR GDVVPKDVTA AVAVIKTKRT IQFVDWCPTG FKCGINYQAP
370 380 390 400 410 420
SVVPGGDLAK VQRALCMISN TTAIAEVFSR IDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
430 440
AREDLAALEK DYEEVGAETV GDDEAEEEM