P04079

PR
Gene name
guaA (b2507, JW2491)
Protein name
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthetase, GMPS, Glutamine amidotransferase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2507
EC number
6.3.5.2: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P04079

Entry ID Method Resolution Chain Position Source
1GPM X-ray 220 A A/B/C/D 1-525 PDB
AF-P04079-F1 Predicted AlphaFoldDB

No variants for P04079

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04079

No associated diseases with P04079

5 regional properties for P04079

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 212 - 525 IPR001674
domain GMP synthase, glutamine amidotransferase 10 - 205 IPR004739
domain Glutamine amidotransferase 12 - 199 IPR017926
domain NAD/GMP synthase 223 - 257 IPR022310
domain GMP synthetase ATP pyrophosphatase domain 208 - 400 IPR025777

Functions

Description
EC Number 6.3.5.2 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GMP synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+).
GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
identical protein binding Binding to an identical protein or proteins.
pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.

2 GO annotations of biological process

Name Definition
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTENIHKHRI LILDFGSQYT QLVARRVREL GVYCELWAWD VTEAQIRDFN PSGIILSGGP
70 80 90 100 110 120
ESTTEENSPR APQYVFEAGV PVFGVCYGMQ TMAMQLGGHV EASNEREFGY AQVEVVNDSA
130 140 150 160 170 180
LVRGIEDALT ADGKPLLDVW MSHGDKVTAI PSDFITVAST ESCPFAIMAN EEKRFYGVQF
190 200 210 220 230 240
HPEVTHTRQG MRMLERFVRD ICQCEALWTP AKIIDDAVAR IREQVGDDKV ILGLSGGVDS
250 260 270 280 290 300
SVTAMLLHRA IGKNLTCVFV DNGLLRLNEA EQVLDMFGDH FGLNIVHVPA EDRFLSALAG
310 320 330 340 350 360
ENDPEAKRKI IGRVFVEVFD EEALKLEDVK WLAQGTIYPD VIESAASATG KAHVIKSHHN
370 380 390 400 410 420
VGGLPKEMKM GLVEPLKELF KDEVRKIGLE LGLPYDMLYR HPFPGPGLGV RVLGEVKKEY
430 440 450 460 470 480
CDLLRRADAI FIEELRKADL YDKVSQAFTV FLPVRSVGVM GDGRKYDWVV SLRAVETIDF
490 500 510 520
MTAHWAHLPY DFLGRVSNRI INEVNGISRV VYDISGKPPA TIEWE