P04068

PR
Gene name
EPHX1
Protein name
Epoxide hydrolase 1
Names
Epoxide hydratase, Microsomal epoxide hydrolase, mEH
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009104
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P04068

Entry ID Method Resolution Chain Position Source
AF-P04068-F1 Predicted AlphaFoldDB

No variants for P04068

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04068

No associated diseases with P04068

1 regional properties for P04068

Type Name Position InterPro Accession
domain Epoxide hydrolase, N-terminal 48 - 157 IPR010497

Functions

Description
EC Number
Subcellular Localization
  • Microsome membrane ; Single-pass type III membrane protein
  • Endoplasmic reticulum membrane ; Single-pass type III membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
cis-stilbene-oxide hydrolase activity Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol.

3 GO annotations of biological process

Name Definition
arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLELLLASV LGFVIYWFVS GDKEESLPLE DGWWGPGSRP VGLEDESIRP FKVETSDEEI
70 80 90 100 110 120
NDLHQRIDRI RLTPPLENSR FHYGFNSNYL KKILSYWRHE FDWKKQVEIL NSYPHFKTKI
130 140 150 160 170 180
EGLDIHFIHV KPPQVPPGRT PKPLLMVHGW PGSFFEFYKI IPLLTDPKSH GLSDEHIFEV
190 200 210 220 230 240
ICPSIPGYGF SQASSKKGFN SVSTARIFYK LMLRLGFQEF YIQGGDWGAL VCTNMAQLVP
250 260 270 280 290 300
SHVKGLHLNM ALILRNHYTL TLLLGRRIGG LLGYTERDME LLYPFKEKVF YSLMRESGYM
310 320 330 340 350 360
HIRATKPDTV GCALNDSPVG LAAYILEKFS TWTNSEFRDL EDGGLERKFS LQDLLTNIMI
370 380 390 400 410 420
YWTTGSIVSS QRYYKENLGQ GFMAHKHERL KVHVPTGFAA FPCEIMHVPE KWVRTKYPQL
430 440 450
ISYSYMPRGG HFAAFEEPEL LARDICKFVG LVERQ