P04048
Gene name |
V-KIT |
Protein name |
Tyrosine-protein kinase transforming protein kit |
Names |
|
Species |
Feline sarcoma virus (strain Hardy-Zuckerman 4) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P04048
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P04048
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P04048 | |||||
No associated diseases with P04048
6 regional properties for P04048
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 27 - 370 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 27 - 361 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 86 - 99 | IPR001824 |
| active_site | Tyrosine-protein kinase, active site | 226 - 238 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 33 - 61 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 27 - 362 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| EEINGNNYID | PTQLPYDHKW | EFPRNRLSFG | KTLGAGAFGK | VVEATAYGLI | KSDAAMTVAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KMLKPSAHLT | EREALMSELK | VLSYLGNHMN | IVNLLGACTV | GGPTLVITEY | CCYGDLLNFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRKRDSFICS | KQEDHAEVAL | YKNLLQSKES | SCNDSTNEYM | DMKPGVSYVV | PTKADKRRSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIGSYIERDV | TPAIMEDGEL | ALDLEDLLSF | SYQVAKGMAF | LASKNCIHRD | LAARNILLTH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRITKICDFG | LARDIKNDSN | YVVKGNARLP | VKWMAPESIF | NCVYTFESDV | WSYGIFLWEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSLGSSPYPG | MPVDSKFYKM | IKEGFRMLSP | EHAPAEMYDI | MKTCWDADPL | KRPTFKQIVQ |
| LIEKQKNKNE |