P04037

PR
Gene name
COX4 (YGL187C, G1362)
Protein name
Cytochrome c oxidase subunit 4, mitochondrial
Names
Cytochrome c oxidase polypeptide IV
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGL187C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P04037

Entry ID Method Resolution Chain Position Source
1HR8 X-ray 270 A O/P/Q/R 2-25 PDB
2ODX NMR - A 79-155 PDB
6GIQ EM 323 A d 1-155 PDB
6HU9 EM 335 A d/p 26-155 PDB
6T0B EM 280 A d/q 26-155 PDB
6T15 EM 329 A d 26-155 PDB
6YMX EM 317 A d 30-146 PDB
6YMY EM 341 A d 30-146 PDB
7CLV NMR - C 1-25 PDB
7Z10 EM 387 A d 29-149 PDB
8DH6 EM 294 A d 26-155 PDB
8E7S EM 320 A T/t 1-155 PDB
8EC0 EM 330 A T 1-155 PDB
AF-P04037-F1 Predicted AlphaFoldDB

No variants for P04037

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P04037

No associated diseases with P04037

No regional properties for P04037

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P04037

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial respiratory chain complex IV A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
cellular respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
mitochondrial cytochrome c oxidase assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.
mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV.
proton transmembrane transport The directed movement of a proton across a membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG AKEGTVPTDL
70 80 90 100 110 120
DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII ESYDDYRYVG CTGSPAGSHT
130 140 150
IMWLKPTVNE VARCWECGSV YKLNPVGVPN DDHHH