AiPD: Autoinhibited Protein Database

P04035

Gene name	HMGCR
Protein name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names	HMG-CoA reductase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3156
EC number	1.1.1.34: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-461 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

392-461 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

23 structures for P04035

Entry ID	Method	Resolution	Chain	Position	Source
1DQ8	X-ray	210 A	A/B/C/D	426-888	PDB
1DQ9	X-ray	280 A	A/B/C/D	426-888	PDB
1DQA	X-ray	200 A	A/B/C/D	426-888	PDB
1HW8	X-ray	210 A	A/B/C/D	426-888	PDB
1HW9	X-ray	233 A	A/B/C/D	426-888	PDB
1HWI	X-ray	230 A	A/B/C/D	426-888	PDB
1HWJ	X-ray	226 A	A/B/C/D	426-888	PDB
1HWK	X-ray	222 A	A/B/C/D	426-888	PDB
1HWL	X-ray	210 A	A/B/C/D	426-888	PDB
2Q1L	X-ray	205 A	A/B/C/D	441-875	PDB
2Q6B	X-ray	200 A	A/B/C/D	441-875	PDB
2Q6C	X-ray	200 A	A/B/C/D	441-875	PDB
2R4F	X-ray	170 A	A/B/C/D	441-875	PDB
3BGL	X-ray	223 A	A/B/C/D	441-875	PDB
3CCT	X-ray	212 A	A/B/C/D	441-875	PDB
3CCW	X-ray	210 A	A/B/C/D	441-875	PDB
3CCZ	X-ray	170 A	A/B/C/D	441-875	PDB
3CD0	X-ray	240 A	A/B/C/D	441-875	PDB
3CD5	X-ray	239 A	A/B/C/D	441-875	PDB
3CD7	X-ray	205 A	A/B/C/D	441-875	PDB
3CDA	X-ray	207 A	A/B/C/D	441-875	PDB
3CDB	X-ray	230 A	A/B/C/D	441-875	PDB
AF-P04035-F1	Predicted				AlphaFoldDB

433 variants for P04035

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs751171582 CA360299141	7	R>L		No	ClinGen ExAC TOPMed gnomAD
CA360299139 rs751171582	7	R>P		No	ClinGen ExAC TOPMed gnomAD
rs751171582 CA3308353	7	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1051046202 CA120881531	8	M>T		No	ClinGen Ensembl
rs1267761914 CA360299147	8	M>V		No	ClinGen gnomAD
rs1399840363 CA360299169	9	H>R		No	ClinGen gnomAD
TCGA novel	10	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308354 rs763611929	14	A>G		No	ClinGen ExAC TOPMed gnomAD
CA360299236 rs763611929	14	A>V		No	ClinGen ExAC TOPMed gnomAD
CA360299260 rs1201009521	16	H>P		No	ClinGen gnomAD
rs1416769598 CA360299275	17	P>A		No	ClinGen gnomAD
rs780893840 CA3308355	20	V>F		No	ClinGen ExAC gnomAD
CA3308356 rs745371345	21	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1273881990 CA360299372	22	V>A		No	ClinGen TOPMed
rs1218851648 CA360299399	25	V>M		No	ClinGen TOPMed
rs367706109 CA3308359	27	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA360299463 rs1561194850	30	C>G		No	ClinGen Ensembl
CA3308360 rs769016687	31	M>V		No	ClinGen ExAC gnomAD
rs371769368 CA3308361	32	M>T		No	ClinGen ESP ExAC gnomAD
CA120881608 rs1009595037	35	N>S		No	ClinGen Ensembl
CA3308362 rs201541062	36	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA360299615 rs1381654025	40	N>S		No	ClinGen TOPMed gnomAD
CA3308363 rs772179314	41	N>S		No	ClinGen ExAC gnomAD
rs773624826 CA3308364	43	I>V		No	ClinGen ExAC gnomAD
TCGA novel	47	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369987181 CA3308367	50	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA360299772 rs369987181	50	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3308368 rs764673047	53	F>S		No	ClinGen ExAC TOPMed gnomAD
CA3308397 rs765808919	56	D>E		No	ClinGen ExAC gnomAD
CA360300021 rs1232088692	59	S>G		No	ClinGen gnomAD
rs1178012749 CA360300072	62	I>V		No	ClinGen gnomAD
TCGA novel	64	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1479509540 CA360300133 COSM3393666	67	I>V	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1580655061 CA360300157	69	R>*		No	ClinGen Ensembl
CA360300158 rs1430662318	69	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1487837370 CA360300170	70	C>F		No	ClinGen gnomAD
TCGA novel	70	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320230215 CA360300182	71	I>V		No	ClinGen Ensembl
CA3308398 rs753282492	73	I>V		No	ClinGen ExAC gnomAD
CA360300377 rs1354325261	84	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs372565038 CA3308399 COSM3429632	84	R>H	large_intestine Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA3308421 rs758983271	97	L>H		No	ClinGen ExAC gnomAD
CA360300925 rs1222036418	109	V>G		No	ClinGen gnomAD
CA360301013 rs1580655350	114	L>V		No	ClinGen Ensembl
CA3308423 rs751963403	115	D>N		No	ClinGen ExAC gnomAD
rs1335822230 CA360301109	118	L>W		No	ClinGen gnomAD
rs781242828 CA3308425	119	T>S		No	ClinGen ExAC gnomAD
rs1327209409 CA360302334	126	P>S		No	ClinGen TOPMed
CA360302377 rs1458297649	128	F>L		No	ClinGen gnomAD
rs1334645817 CA360302446	131	L>V		No	ClinGen gnomAD
rs538995429 CA360302486	133	D>H		No	ClinGen gnomAD
CA120883929 rs538995429	133	D>N		No	ClinGen gnomAD
CA3308445 rs781639869	136	R>K		No	ClinGen ExAC gnomAD
rs750553430 CA3308446	137	A>G		No	ClinGen ExAC gnomAD
rs756363474 CA3308447	139	T>I		No	ClinGen ExAC gnomAD
CA3308448 rs780209976	142	K>T		No	ClinGen ExAC
rs749358438 CA3308449	145	L>F		No	ClinGen ExAC TOPMed gnomAD
CA360302688 rs1261841370	146	S>R		No	ClinGen gnomAD
CA120883957 rs112503211	147	S>P		No	ClinGen Ensembl
CA360302906 rs1196744403	151	D>E		No	ClinGen TOPMed gnomAD
rs1483815731 CA360302894	151	D>N		No	ClinGen gnomAD
CA3308462 rs774953568	155	E>K		No	ClinGen ExAC gnomAD
CA120885119 rs761181428	157	I>L		No	ClinGen Ensembl
CA3308464 rs368129510	159	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3308465 rs139887868	159	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA360303063 rs1439339442	163	I>V		No	ClinGen gnomAD
TCGA novel	164	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360303104 rs1371472683	166	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1045190482 COSM1438564 CA120885147	167	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs754097995 CA3308468	171	D>N		No	ClinGen ExAC gnomAD
CA360303184 rs1273046862	172	A>V		No	ClinGen TOPMed
CA120885190 rs776974055	173	L>F		No	ClinGen Ensembl
CA3308469 rs755011121	173	L>H		No	ClinGen ExAC gnomAD
CA360303208 rs1164535656	175	E>*		No	ClinGen gnomAD
CA120885234 rs528117857	176	C>R		No	ClinGen gnomAD
rs778985768 CA3308470	178	V>L		No	ClinGen ExAC gnomAD
rs1219815518 CA360303313	181	V>A		No	ClinGen gnomAD
rs757219169 CA3308472	182	G>S		No	ClinGen ExAC gnomAD
CA360303340 rs1488541764	183	T>N		No	ClinGen gnomAD
rs1259637958 CA360303357	184	M>T		No	ClinGen TOPMed gnomAD
CA360117293 rs1321843698	188	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs552138456 CA120915359	188	R>H		No	ClinGen TOPMed gnomAD
CA360117370 rs1580660222	193	M>L		No	ClinGen Ensembl
CA3308493 rs758462507	193	M>R		No	ClinGen ExAC gnomAD
rs200260317 CA120915379	202	L>V		No	ClinGen gnomAD
rs750361584 CA3308495	204	N>D		No	ClinGen ExAC TOPMed gnomAD
CA3308496 rs148335635	204	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140490718 CA3308498	206	F>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA360117597 rs768419319	206	F>L		No	ClinGen ExAC TOPMed gnomAD
CA360117620 rs1208512488	208	F>L		No	ClinGen TOPMed
rs1314438103 CA360117637	209	M>L		No	ClinGen TOPMed
rs778768497 CA3308500	214	A>G		No	ClinGen ExAC gnomAD
CA360117717 rs1237825871	215	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs147043821 CA3308501	218	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA360117773 rs937171936 CA120915396	219	V>L		No	ClinGen gnomAD
TCGA novel	221	E>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308511 rs373417164	224	R>L		No	ClinGen ESP ExAC gnomAD
CA360117885 rs373417164	224	R>Q		No	ClinGen ESP ExAC gnomAD
rs1051691944 CA120915498	225	E>D		No	ClinGen TOPMed gnomAD
rs750322057 CA3308512	226	S>N		No	ClinGen ExAC gnomAD
CA3308513 rs756129604	227	R>C		No	ClinGen ExAC gnomAD
TCGA novel	228	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1254056455 CA360117953	229	G>V		No	ClinGen gnomAD
rs780208977 CA3308514	230	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3308515 rs753673014 COSM3768864	230	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA360117966 rs753673014	230	R>L		No	ClinGen ExAC TOPMed gnomAD
CA120915532 rs1005567773	232	I>V		No	ClinGen TOPMed
rs1200550176 CA360118017	233	W>C		No	ClinGen TOPMed gnomAD
rs778678847 CA3308517	233	W>S		No	ClinGen ExAC gnomAD
CA360118061 rs1168738941 CA360118062	236	S>R		No	ClinGen TOPMed gnomAD
rs763132410 CA120915539	236	S>T		No	ClinGen Ensembl
CA3308518 rs747786153	240	R>P		No	ClinGen ExAC gnomAD
rs1287584125 CA360118139	241	V>G		No	ClinGen TOPMed
CA360118177 rs1309410379	244	E>K		No	ClinGen gnomAD
rs1369619869 CA360118294	247	N>K		No	ClinGen gnomAD
CA120915573 rs879389443	247	N>S		No	ClinGen gnomAD
CA3308524 rs777178244 COSM3828419	249	P>L	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA360118365 rs1397491532	251	P>H		No	ClinGen TOPMed
rs770177852 CA3308526	251	P>T		No	ClinGen ExAC gnomAD
rs1379638521 CA360118413	254	Q>*		No	ClinGen TOPMed
rs1206139538 COSM3828421 CA360118436	254	Q>H	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	257	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360118560 rs1276987292	259	I>F		No	ClinGen gnomAD
CA360118739 rs1290662562	261	S>C		No	ClinGen gnomAD
rs1174834522 CA360118815	265	V>A		No	ClinGen TOPMed
CA3308544 rs781640240	265	V>I		No	ClinGen ExAC gnomAD
CA3308545 rs781640240	265	V>L		No	ClinGen ExAC gnomAD
CA3308546 rs770089730	267	V>F		No	ClinGen ExAC
CA3308548 rs377514952	269	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1472261028 CA360118893	270	H>Y		No	ClinGen gnomAD
CA120915882 rs1025150103	272	R>C		No	ClinGen TOPMed
rs768747516 CA3308549	272	R>H		No	ClinGen ExAC gnomAD
CA360119022 rs1415352636	274	I>M		No	ClinGen gnomAD
CA120915895 rs1051258640	275	A>S		No	ClinGen Ensembl
CA360119070 rs1467674358	276	D>E		No	ClinGen TOPMed gnomAD
rs544999212 CA120915907	276	D>V		No	ClinGen 1000Genomes
COSM1642787 rs144780232 CA3308552	277	P>L	stomach [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA3308551 rs774684544	277	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1398934713 CA360119111	278	S>C		No	ClinGen gnomAD
rs554100316	279	P>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA360119165 rs1334440584	280	Q>H		No	ClinGen gnomAD
rs1014962118 CA120915926	281	N>K		No	ClinGen TOPMed gnomAD
rs767738315 CA3308554	282	S>G		No	ClinGen ExAC gnomAD
CA360119246 rs1284931549	283	T>I		No	ClinGen gnomAD
CA3308556 rs759558565	286	T>I		No	ClinGen ExAC gnomAD
rs1268105693 CA360119332	287	S>A		No	ClinGen gnomAD
CA3308557 rs139776831	288	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA360119381 rs1238114836	289	V>I		No	ClinGen TOPMed
rs968339885 CA120915945	290	S>P		No	ClinGen Ensembl
CA360119433 rs1211048424	291	L>I		No	ClinGen gnomAD
CA3308558 rs752430097	293	L>V		No	ClinGen ExAC gnomAD
CA3308560 rs763628844	294	D>H		No	ClinGen ExAC gnomAD
CA120915993 rs1029103328	303	P>L		No	ClinGen TOPMed
CA3308563 rs780697550	305	V>A		No	ClinGen ExAC TOPMed gnomAD
rs780697550 CA3308564	305	V>D		No	ClinGen ExAC TOPMed gnomAD
rs1034058316 CA120916028	308	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA120916013 rs946025973	308	W>S		No	ClinGen TOPMed gnomAD
CA3308565 rs756578585	309	Q>P		No	ClinGen ExAC gnomAD
CA360119882 rs1396354367	310	F>I		No	ClinGen gnomAD
rs191835914 CA3308567	311	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs191835914 CA3308566	311	Y>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755250925 CA3308586	315	M>V		No	ClinGen ExAC gnomAD
rs577513968 CA120916167	316	I>M		No	ClinGen Ensembl
rs1299874052 CA360120181	316	I>N		No	ClinGen TOPMed gnomAD
rs1181601971 CA360120242	318	M>I		No	ClinGen TOPMed gnomAD
TCGA novel CA360120212 rs1580661332	318	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs779431841 CA3308587	320	I>T		No	ClinGen ExAC gnomAD
CA360120328 rs1234503403	322	Q>K		No	ClinGen gnomAD
rs1258120929 CA360120360	323	V>I		No	ClinGen gnomAD
CA3308589 rs772418448	324	I>T		No	ClinGen ExAC gnomAD
CA3308588 rs748312589	324	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1274862704 CA360120542	330	L>F		No	ClinGen gnomAD
rs1483764038 CA360120556	331	L>F		No	ClinGen gnomAD
rs1207529910 CA360120681	333	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1561200001 CA360120830	338	F>C		No	ClinGen Ensembl
CA360120810 rs1200812097	338	F>I		No	ClinGen gnomAD
TCGA novel	338	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308591 rs559001934	342	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA3308592 rs370386875	343	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA360121035 rs1168235119	344	T>I		No	ClinGen gnomAD
CA3308593 rs775249201	347	T>I		No	ClinGen ExAC gnomAD
CA360121323 rs1291850857	354	I>L		No	ClinGen TOPMed gnomAD
rs144482710 CA3308597 COSM450053	354	I>M	Variant assessed as Somatic; 0.0001392 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs374534527 CA3308596	354	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3308598 rs774131030	355	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	356	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360121439 rs1476406557	359	V>G		No	ClinGen TOPMed
rs767134717 CA3308600	360	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	362	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs934071408 CA120916274	364	V>I		No	ClinGen Ensembl
rs760064646 CA3308602	365	P>L		No	ClinGen ExAC TOPMed gnomAD
rs760064646 CA360121598	365	P>R		No	ClinGen ExAC TOPMed gnomAD
CA3308604 rs780343008	367	N>S	Variant assessed as Somatic; 4.652e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA3308606 rs200102303	368	C>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1488490498 CA360121748	371	R>C		No	ClinGen TOPMed gnomAD
CA3308607 rs779630004	371	R>H		No	ClinGen ExAC TOPMed gnomAD
CA360121800 rs1561200130	374	M>V		No	ClinGen Ensembl
CA3308608 rs753098010	377	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	380	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1172684208 CA360121974	382	C>W		No	ClinGen TOPMed
CA360122022 rs1410434945	385	V>A		No	ClinGen TOPMed
rs1188928731 CA360122079	388	E>G		No	ClinGen gnomAD
CA360122066 rs1424435627	388	E>K		No	ClinGen TOPMed
rs1391085687 CA360122098	389	T>R		No	ClinGen TOPMed gnomAD
CA120916295 rs953466803	392	N>T		No	ClinGen TOPMed
CA360122158 rs371909330	393	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs376488768 CA3308610	393	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA360122171 rs1256523877	394	E>Q		No	ClinGen TOPMed
CA3308611 rs747283372	397	V>I		No	ClinGen ExAC gnomAD
rs1301923319 CA360122438	406	E>K		No	ClinGen gnomAD
TCGA novel	409	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308631 rs751667502	409	T>S		No	ClinGen ExAC gnomAD
TCGA novel	410	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308632 rs757499420	410	P>R		No	ClinGen ExAC gnomAD
CA3308633 rs781331129	411	N>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs201862213 CA3308634	411	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1269895716 CA360122587	413	A>T		No	ClinGen TOPMed gnomAD
rs1310241139 CA360123383	414	T>I		No	ClinGen gnomAD
CA3308636 rs778783315	415	F>Y		No	ClinGen ExAC gnomAD
rs1013975113 CA120916386	418	G>S		No	ClinGen Ensembl
CA360123441 rs1483699305	418	G>V		No	ClinGen gnomAD
rs1472268913 CA360123473	421	S>F		No	ClinGen gnomAD
rs1183580711 CA360123477	422	L>S		No	ClinGen TOPMed gnomAD
CA360123481 rs1410742369	423	L>F		No	ClinGen TOPMed gnomAD
CA120916407 rs200965407	424	D>G		No	ClinGen 1000Genomes
rs146188615 CA3308639	424	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs146188615 CA3308640	424	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	426	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	428	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360123532 rs1376043825	431	T>I		No	ClinGen TOPMed
CA360123541 rs1580661906	433	E>K		No	ClinGen Ensembl
CA3308643 rs776190879	434	P>A		No	ClinGen ExAC gnomAD
rs759085544 CA3308644	434	P>L		No	ClinGen ExAC gnomAD
TCGA novel	435	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs544507554 CA3308645	435	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA360123557 rs1365367233	435	E>V		No	ClinGen gnomAD
rs1280869625 CA360123568	437	E>*		No	ClinGen gnomAD
rs776090392 CA3308646	437	E>G		No	ClinGen ExAC gnomAD
rs776090392 CA360123571	437	E>V		No	ClinGen ExAC gnomAD
rs1024480102 CA120916435	440	R>G		No	ClinGen gnomAD
rs1313677728 CA360123587	440	R>K		No	ClinGen gnomAD
rs1213300878 CA360123600	442	P>T		No	ClinGen gnomAD
rs982576013 CA120916456	443	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs951205085 CA120916454	443	R>W		No	ClinGen Ensembl
rs1016757703 CA120916460	446	E>G		No	ClinGen gnomAD
CA360123623 rs1580661972 COSM1329450	446	E>K	ovary [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	447	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308649 rs373019218	453	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1166350554 CA360123684	454	N>K		No	ClinGen gnomAD
CA360123682 rs1455823831	454	N>S		No	ClinGen gnomAD
rs139058364 CA3308666	460	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA360123992 rs1365578921	465	A>V		No	ClinGen gnomAD
CA3308668 rs774760918	472	N>D		No	ClinGen ExAC gnomAD
rs1227787204 CA360124047	473	A>G		No	ClinGen TOPMed gnomAD
rs767798571 CA3308670	477	P>S		No	ClinGen ExAC TOPMed gnomAD
rs750588723 CA3308671	478	A>D		No	ClinGen ExAC TOPMed
CA360124078 rs1207292158	478	A>S		No	ClinGen TOPMed gnomAD
CA3308673 rs766652276	479	Y>*		No	ClinGen ExAC gnomAD
rs1465577182 CA360124086	479	Y>C		No	ClinGen gnomAD
rs753898770 CA3308674	480	K>N		No	ClinGen ExAC gnomAD
TCGA novel	482	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1297383354 CA360124120	484	L>P		No	ClinGen gnomAD
CA360124163 rs1277575286	490	R>C		No	ClinGen TOPMed
CA360124166 rs1476674144	490	R>H		No	ClinGen Ensembl
rs755095283 CA3308675	491	G>D		No	ClinGen ExAC gnomAD
CA3308676 rs777730853	492	V>I		No	ClinGen ExAC gnomAD
rs751482798 CA360124177	493	S>A		No	ClinGen ExAC gnomAD
rs751482798 CA3308677	493	S>P		No	ClinGen ExAC gnomAD
rs757026862 CA3308678	495	R>C		No	ClinGen ExAC TOPMed gnomAD
CA360124196 COSM1209815 rs1438532336	496	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA360124227 rs1383652871	499	L>P		No	ClinGen gnomAD
rs1320586148 CA360124243	500	S>C		No	ClinGen TOPMed gnomAD
rs1320586148 CA360124245	500	S>F		No	ClinGen TOPMed gnomAD
TCGA novel	506	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	510	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768082953 CA3308684	515	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1227098072 COSM333190 CA360124603	520	S>F	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1357383246 CA360124596	520	S>P		No	ClinGen gnomAD
rs747762857 CA3308703	525	A>V		No	ClinGen ExAC TOPMed gnomAD
CA120918642 rs914988309	526	C>S		No	ClinGen TOPMed gnomAD
CA360124804 rs1376869865	531	I>T		No	ClinGen gnomAD
rs1478204770 CA360124819	532	G>E		No	ClinGen gnomAD
CA360124867 rs1187682242	535	P>S		No	ClinGen TOPMed
rs1174529981 CA360124931	539	G>R		No	ClinGen gnomAD
CA3308705 rs773755045	543	P>A		No	ClinGen ExAC gnomAD
rs747339893 CA360125020	544	L>H		No	ClinGen ExAC gnomAD
CA3308706 rs747339893	544	L>P		No	ClinGen ExAC gnomAD
rs1580665186 CA360125070	546	L>F		No	ClinGen Ensembl
rs1393646412 CA360125078	547	D>N		No	ClinGen gnomAD
rs1249776714 CA360125241	555	M>V		No	ClinGen TOPMed
CA3308708 rs776785264	557	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1330923036 CA360125328	562	L>P		No	ClinGen gnomAD
TCGA novel	565	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	567	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	567	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1580665230 CA360125383	570	C>W		No	ClinGen Ensembl
CA3308709 rs759690331	574	G>D		No	ClinGen ExAC gnomAD
rs199707836 CA120918835	582	R>*		No	ClinGen 1000Genomes
rs554601529 CA3308724	582	R>Q		No	ClinGen ExAC gnomAD
CA360125478 rs1177327232	584	L>F		No	ClinGen TOPMed gnomAD
CA360125501 rs1215403348	587	G>A		No	ClinGen gnomAD
rs910624160 CA120918844	588	M>I		No	ClinGen Ensembl
rs1245965565 CA360125519	590	R>H		No	ClinGen gnomAD
rs1464223287 CA360125538	593	V>A		No	ClinGen TOPMed gnomAD
CA3308725 rs193026499	595	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381726485 CA360125548	595	R>H		No	ClinGen gnomAD
rs746309868 CA3308726	596	L>F		No	ClinGen ExAC gnomAD
CA3308727 rs769892997	597	P>A		No	ClinGen ExAC gnomAD
rs775823773 CA3308728	598	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1228694899 CA360125563	598	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1417859624 CA360125575	600	C>Y		No	ClinGen gnomAD
CA120918865 rs1047128169	603	A>G		No	ClinGen TOPMed
rs764291157 CA3308730	608	W>S		No	ClinGen ExAC gnomAD
CA360125639 rs1157760710	609	L>P		No	ClinGen gnomAD
rs766494307 CA3308733	610	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA360125681 rs754848272	615	F>L		No	ClinGen ExAC TOPMed gnomAD
CA3308736 rs764763607	616	A>S		No	ClinGen ExAC TOPMed gnomAD
CA3308737 rs764763607 COSM1070105	616	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1480735729 CA360125699	619	K>Q		No	ClinGen TOPMed
rs1311831907 CA360125786	628	F>L		No	ClinGen gnomAD
CA3308752 rs762045069	630	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3308753 rs375866343	630	R>H		No	ClinGen ESP ExAC gnomAD
rs1198685590 CA360125828	631	L>P		No	ClinGen TOPMed gnomAD
rs896113185 CA360125834	632	Q>*		No	ClinGen TOPMed
rs896113185 CA120919595	632	Q>K		No	ClinGen TOPMed
rs759209951 CA3308755	632	Q>R		No	ClinGen ExAC gnomAD
CA360125854 rs1224198024	633	K>R		No	ClinGen gnomAD
rs765098078 CA3308756	635	H>Y		No	ClinGen ExAC gnomAD
CA3308758 rs762597156	637	S>R		No	ClinGen ExAC gnomAD
rs539946792 CA120919615	638	I>T		No	ClinGen Ensembl
rs5908 VAR_011954 CA3308759	638	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA120919617 rs1026466838	639	A>T		No	ClinGen TOPMed
CA120919623 rs1022189398	641	R>C		No	ClinGen gnomAD
CA120919624 rs369102555	643	L>V		No	ClinGen ESP
CA360126021 rs1345725679	646	R>C		No	ClinGen TOPMed
rs1307067018 CA360126046	648	Q>E		No	ClinGen TOPMed
CA360126110 rs781513148	653	D>H		No	ClinGen ExAC TOPMed gnomAD
CA360126108 rs781513148	653	D>N		No	ClinGen ExAC TOPMed gnomAD
rs781513148 CA3308762	653	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA120919667 rs866589749	654	A>V		No	ClinGen Ensembl
CA3308763 rs750964538	659	M>V		No	ClinGen ExAC TOPMed gnomAD
rs980728664 CA120919694	660	I>T		No	ClinGen Ensembl
rs147818666 CA3308778	663	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA360126998 rs1409999841	663	G>R		No	ClinGen gnomAD
rs1312499714 CA360127071	669	S>L		No	ClinGen TOPMed
CA3308779 rs200606736	673	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA360127202 rs1402562693	679	Q>E		No	ClinGen gnomAD
CA3308780 rs750830196	679	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3308781 rs756643814	680	I>F		No	ClinGen ExAC gnomAD
rs551439059 CA3308784 COSM1070106	683	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA3308786 rs748402261	689	T>I		No	ClinGen ExAC gnomAD
CA360127396 rs1580668539	692	K>N		No	ClinGen Ensembl
rs1470069403 CA360127440	696	I>V		No	ClinGen gnomAD
rs1411619753 CA360127559	704	K>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA360127574 rs747124451	705	S>C		No	ClinGen ExAC gnomAD
CA3308789 rs747124451	705	S>Y		No	ClinGen ExAC gnomAD
TCGA novel	710	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs565279114 CA3308790	711	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA3308791 rs373896859	716	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1316546330 CA360127905	719	E>K		No	ClinGen gnomAD
rs1219802002 CA360128097	720	V>A		No	ClinGen gnomAD
CA3308809 rs757319136	720	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1414213066 CA360128245	726	E>Q		No	ClinGen gnomAD
CA3308812 rs768373804	728	M>V		No	ClinGen ExAC gnomAD
rs1357902378 CA360128335	730	E>D		No	ClinGen gnomAD
CA360128369 rs1561205544	733	I>V		No	ClinGen Ensembl
rs774128813 CA3308813	736	N>S		No	ClinGen ExAC gnomAD
rs1351777438 CA360128450	738	V>A		No	ClinGen gnomAD
rs772783149 CA3308816	743	A>T		No	ClinGen ExAC gnomAD
rs760121176 CA3308820	749	Y>C		No	ClinGen ExAC gnomAD
rs1471016934 CA360128628	752	H>R		No	ClinGen gnomAD
TCGA novel	756	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360128655 rs1171672440	756	I>T		No	ClinGen TOPMed
CA120921612 rs1022726841	756	I>V		No	ClinGen TOPMed
CA3308825 rs201093294	757	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA360128663 rs1580668952	758	T>P		No	ClinGen Ensembl
rs1199407498 CA360128669	759	A>T		No	ClinGen TOPMed
rs1457315659 CA360128674	759	A>V		No	ClinGen TOPMed
CA360128675 rs1390180343	760	I>V		No	ClinGen gnomAD
CA3308828 rs750568326	761	Y>C		No	ClinGen ExAC gnomAD
rs1336752860 CA360128689	762	I>L		No	ClinGen gnomAD
rs1336752860 CA360128690	762	I>V		No	ClinGen gnomAD
CA360128765 rs1196883888	766	Q>*		No	ClinGen TOPMed
CA120921770 rs914153249	773	G>A		No	ClinGen Ensembl
CA3308845 rs763336817	773	G>S		No	ClinGen ExAC gnomAD
CA360129170 rs1340237683	783	A>E		No	ClinGen gnomAD
CA360129169 rs1324309717	783	A>S		No	ClinGen gnomAD
TCGA novel	788	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1370645233 CA360129204	788	N>S		No	ClinGen gnomAD
rs751738204 CA3308848	796	T>A		No	ClinGen ExAC
CA360129266 rs1275707157	796	T>I		No	ClinGen Ensembl
CA360129291 rs1580669140	800	I>T		No	ClinGen Ensembl
rs754242135 CA3308849	800	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1226031610 CA360129408	809	T>N		No	ClinGen gnomAD
CA3308851 rs750482473	814	Q>H		No	ClinGen ExAC gnomAD
rs1211667812 CA360129572	818	L>M		No	ClinGen gnomAD
rs756229383 CA3308852	819	Q>P		No	ClinGen ExAC gnomAD
rs756229383 CA120921824	819	Q>R		No	ClinGen ExAC gnomAD
CA3308871 rs766378658	824	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs752608685 CA3308872	826	A>G		No	ClinGen ExAC TOPMed gnomAD
rs758261635 CA3308873	827	C>R		No	ClinGen ExAC gnomAD
rs764148209 CA3308874	829	D>Y		No	ClinGen ExAC gnomAD
rs944760621 CA120922154	830	N>K		No	ClinGen TOPMed gnomAD
rs1004498004 CA120922160	833	E>G		No	ClinGen Ensembl
rs924424462 CA120922173	836	R>Q		No	ClinGen TOPMed gnomAD
CA120922169 rs1040440340	836	R>W		No	ClinGen TOPMed gnomAD
rs780951743 CA3308877	837	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1259531849 CA360129805	837	Q>R		No	ClinGen TOPMed
rs1452622486 CA360129855	840	R>*		No	ClinGen gnomAD
CA3308879 rs755619444 COSM170965	840	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs996854884 CA120922194	845	T>A		No	ClinGen Ensembl
CA360130146 rs1238646352	854	M>I		No	ClinGen gnomAD
CA3308885 rs772452192	854	M>T		No	ClinGen ExAC gnomAD
rs1304600057 CA360130127	854	M>V		No	ClinGen gnomAD
TCGA novel	861	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360130242 rs1580669708	861	H>Y		No	ClinGen Ensembl
CA3308887 rs760888650	864	K>N		No	ClinGen ExAC gnomAD
CA360130593 rs1208801059	864	K>R		No	ClinGen gnomAD
rs1580669910 CA360130888	871	R>S		No	ClinGen Ensembl
rs1462746598 CA360130813	871	R>T		No	ClinGen TOPMed
rs779242271 CA3308904	872	S>L		No	ClinGen ExAC TOPMed gnomAD
CA3308905 rs748671468	874	I>F		No	ClinGen ExAC gnomAD
CA360130997 rs1580669940	879	L>F		No	ClinGen Ensembl
TCGA novel	880	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3308907 rs772352586	880	Q>K		No	ClinGen ExAC gnomAD
CA3308908 rs778102701	880	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs747429849 CA3308909	882	A>S		No	ClinGen ExAC gnomAD
CA120922402 rs952366348	883	C>S		No	ClinGen TOPMed
CA120922419 rs775023531	885	K>N		No	ClinGen gnomAD
CA3308910 rs771032831	886	K>N		No	ClinGen ExAC gnomAD
rs1368446713 CA360131094	886	K>T		No	ClinGen gnomAD
CA360131105 rs1302902720	887	T>A		No	ClinGen TOPMed gnomAD
rs939863860 CA120922434	887	T>I		No	ClinGen TOPMed gnomAD

No associated diseases with P04035

4 regional properties for P04035

Type	Name	Position	InterPro Accession
domain	Sterol-sensing domain	61 - 222	IPR000731
conserved_site	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	646 - 660	IPR023076-1
conserved_site	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	802 - 809	IPR023076-2
conserved_site	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	856 - 869	IPR023076-3

Functions

		Description
EC Number	1.1.1.34	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein Peroxisome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
peroxisomal membrane	The lipid bilayer surrounding a peroxisome.

3 GO annotations of molecular function

Name	Definition
coenzyme A binding	Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
hydroxymethylglutaryl-CoA reductase (NADPH) activity	Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.
NADPH binding	Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

9 GO annotations of biological process

Name	Definition
cholesterol biosynthetic process	The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
coenzyme A metabolic process	The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
isoprenoid biosynthetic process	The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
negative regulation of amyloid-beta clearance	Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance.
negative regulation of MAP kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
negative regulation of protein catabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.
negative regulation of protein secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
sterol biosynthetic process	The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
visual learning	Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MLSRLFRMHG	LFVASHPWEV	IVGTVTLTIC	MMSMNMFTGN	NKICGWNYEC	PKFEEDVLSS
70	80	90	100	110	120
DIIILTITRC	IAILYIYFQF	QNLRQLGSKY	ILGIAGLFTI	FSSFVFSTVV	IHFLDKELTG
130	140	150	160	170	180
LNEALPFFLL	LIDLSRASTL	AKFALSSNSQ	DEVRENIARG	MAILGPTFTL	DALVECLVIG
190	200	210	220	230	240
VGTMSGVRQL	EIMCCFGCMS	VLANYFVFMT	FFPACVSLVL	ELSRESREGR	PIWQLSHFAR
250	260	270	280	290	300
VLEEEENKPN	PVTQRVKMIM	SLGLVLVHAH	SRWIADPSPQ	NSTADTSKVS	LGLDENVSKR
310	320	330	340	350	360
IEPSVSLWQF	YLSKMISMDI	EQVITLSLAL	LLAVKYIFFE	QTETESTLSL	KNPITSPVVT
370	380	390	400	410	420
QKKVPDNCCR	REPMLVRNNQ	KCDSVEEETG	INRERKVEVI	KPLVAETDTP	NRATFVVGNS
430	440	450	460	470	480
SLLDTSSVLV	TQEPEIELPR	EPRPNEECLQ	ILGNAEKGAK	FLSDAEIIQL	VNAKHIPAYK
490	500	510	520	530	540
LETLMETHER	GVSIRRQLLS	KKLSEPSSLQ	YLPYRDYNYS	LVMGACCENV	IGYMPIPVGV
550	560	570	580	590	600
AGPLCLDEKE	FQVPMATTEG	CLVASTNRGC	RAIGLGGGAS	SRVLADGMTR	GPVVRLPRAC
610	620	630	640	650	660
DSAEVKAWLE	TSEGFAVIKE	AFDSTSRFAR	LQKLHTSIAG	RNLYIRFQSR	SGDAMGMNMI
670	680	690	700	710	720
SKGTEKALSK	LHEYFPEMQI	LAVSGNYCTD	KKPAAINWIE	GRGKSVVCEA	VIPAKVVREV
730	740	750	760	770	780
LKTTTEAMIE	VNINKNLVGS	AMAGSIGGYN	AHAANIVTAI	YIACGQDAAQ	NVGSSNCITL
790	800	810	820	830	840
MEASGPTNED	LYISCTMPSI	EIGTVGGGTN	LLPQQACLQM	LGVQGACKDN	PGENARQLAR
850	860	870	880
IVCGTVMAGE	LSLMAALAAG	HLVKSHMIHN	RSKINLQDLQ	GACTKKTA