P03708

PR
Gene name
A (lambdap02)
Protein name
Terminase, large subunit
Names
DNA-packaging protein A, Large terminase protein, gpA
Species
Escherichia phage lambda (Bacteriophage lambda)
KEGG Pathway
vg:2703524
EC number
3.1.21.4: Endodeoxyribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

584-641 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P03708

Entry ID Method Resolution Chain Position Source

No variants for P03708

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P03708

No associated diseases with P03708

2 regional properties for P03708

Type Name Position InterPro Accession
domain Phage terminase large subunit GpA, ATPase domain 47 - 285 IPR046453
domain Terminase large subunit GpA, endonuclease domain 322 - 600 IPR046454

Functions

Description
EC Number 3.1.21.4 Endodeoxyribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Host cytoplasm
  • The terminase lies at a unique vertex of the procapsid during viral DNA packaging
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
viral terminase, large subunit The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
metal ion binding Binding to a metal ion.
type II site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site.

1 GO annotations of biological process

Name Definition
viral DNA genome packaging The packing of viral DNA into a capsid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNISNSQVNR LRHFVRAGLR SLFRPEPQTA VEWADANYYL PKESAYQEGR WETLPFQRAI
70 80 90 100 110 120
MNAMGSDYIR EVNVVKSARV GYSKMLLGVY AYFIEHKQRN TLIWLPTDGD AENFMKTHVE
130 140 150 160 170 180
PTIRDIPSLL ALAPWYGKKH RDNTLTMKRF TNGRGFWCLG GKAAKNYREK SVDVAGYDEL
190 200 210 220 230 240
AAFDDDIEQE GSPTFLGDKR IEGSVWPKSI RGSTPKVRGT CQIERAASES PHFMRFHVAC
250 260 270 280 290 300
PHCGEEQYLK FGDKETPFGL KWTPDDPSSV FYLCEHNACV IRQQELDFTD ARYICEKTGI
310 320 330 340 350 360
WTRDGILWFS SSGEEIEPPD SVTFHIWTAY SPFTTWVQIV KDWMKTKGDT GKRKTFVNTT
370 380 390 400 410 420
LGETWEAKIG ERPDAEVMAE RKEHYSAPVP DRVAYLTAGI DSQLDRYEMR VWGWGPGEES
430 440 450 460 470 480
WLIDRQIIMG RHDDEQTLLR VDEAINKTYT RRNGAEMSIS RICWDTGGID PTIVYERSKK
490 500 510 520 530 540
HGLFRVIPIK GASVYGKPVA SMPRKRNKNG VYLTEIGTDT AKEQIYNRFT LTPEGDEPLP
550 560 570 580 590 600
GAVHFPNNPD IFDLTEAQQL TAEEQVEKWV DGRKKILWDS KKRRNEALDC FVYALAALRI
610 620 630 640
SISRWQLDLS ALLASLQEED GAATNKKTLA DYARALSGED E