P03502

PR
Gene name
NS
Protein name
Non-structural protein 1
Names
NS1, NS1A
Species
Influenza B virus (strain B/Lee/1940)
KEGG Pathway
vg:26824008
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P03502

Entry ID Method Resolution Chain Position Source
1XEQ X-ray 210 A A/B 1-103 PDB
3R66 X-ray 230 A A/B 1-103 PDB
3RT3 X-ray 201 A C 1-103 PDB
3SDL X-ray 229 A A/B 1-103 PDB
6J62 X-ray 249 A C 1-103 PDB
6JH0 X-ray 240 A A/C 1-103 PDB
6JH1 X-ray 300 A A/B 1-103 PDB

No variants for P03502

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P03502

No associated diseases with P03502

No regional properties for P03502

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P03502

Functions

Description
EC Number
Subcellular Localization
  • Host cytoplasm
  • Host nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

2 GO annotations of molecular function

Name Definition
protein serine/threonine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
suppression by virus of host ISG15-protein conjugation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.
suppression by virus of host PKR signaling Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response.
suppression by virus of host type I interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADNMTTTQI EVGPGATNAT INFEAGILEC YERFSWQRAL DYPGQDRLHR LKRKLESRIK
70 80 90 100 110 120
THNKSEPENK RMSLEERKAI GVKMMKVLLF MDPSAGIEGF EPYCVKNPST SKCPNYDWTD
130 140 150 160 170 180
YPPTPGKYLD DIEEEPENVD HPIEVVLRDM NNKDARQKIK DEVNTQKEGK FRLTIKRDIR
190 200 210 220 230 240
NVLSLRVLVN GTFLKHPNGD KSLSTLHRLN AYDQNGGLVA KLVATDDRTV EDEKDGHRIL
250 260 270 280
NSLFERFDEG HSKPIRAAET AVGVLSQFGQ EHRLSPEEGD N