Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for P03495
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1AIL | X-ray | 190 A | A | 1-72 | PDB |
| 1NS1 | NMR | - | A/B | 1-73 | PDB |
| 2KKZ | NMR | - | A | 85-215 | PDB |
| 2RHK | X-ray | 195 A | A/B | 85-215 | PDB |
| 3EE8 | X-ray | 260 A | A/B | 84-205 | PDB |
| 3EE9 | X-ray | 214 A | A/B | 84-205 | PDB |
| 3KWG | X-ray | 221 A | A/B | 78-205 | PDB |
| 3KWI | X-ray | 221 A | A/B | 78-205 | PDB |
| 4NW2 | X-ray | 190 A | B/D | 216-230 | PDB |
| 4O45 | X-ray | 187 A | B | 216-230 | PDB |
No variants for P03495
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P03495 | |||||
No associated diseases with P03495
No regional properties for P03495
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P03495 | |||
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| host cell cytoplasm | The cytoplasm of a host cell. |
| host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded RNA binding | Binding to double-stranded RNA. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein serine/threonine kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| modulation by symbiont of host intracellular transport | Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| modulation by virus of host transcription | Any process in which a virus modulates the frequency, rate or extent of its host's transcription. |
| suppression by symbiont of host innate immune response | Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| suppression by virus of host cytokine production | Any viral process that results in the inhibition of host cell cytokine production. |
| suppression by virus of host mRNA processing | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| suppression by virus of host PKR signaling | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response. |
| suppression by virus of host type I interferon-mediated signaling pathway | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
| suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity | Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSNTVSSFQ | VDCFLWHVRK | QVVDQELGDA | PFLDRLRRDQ | KSLRGRGSTL | GLNIEAATHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GKQIVEKILK | EESDEALKMT | MASTPASRYI | TDMTIEELSR | DWFMLMPKQK | VEGPLCIRID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QAIMDKNIML | KANFSVIFDR | LETLILLRAF | TEEGAIVGEI | SPLPSFPGHT | IEDVKNAIGV |
| 190 | 200 | 210 | 220 | 230 | |
| LIGGLEWNDN | TVRVSKTLQR | FAWGSSNENG | RPPLTPKQKR | KMARTARSKV | RRDKMAD |