P03261

PR
Gene name
POL
Protein name
DNA polymerase
Names
Species
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
KEGG Pathway
vg:2652985
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P03261

Entry ID Method Resolution Chain Position Source

No variants for P03261

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P03261

No associated diseases with P03261

2 regional properties for P03261

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, mitochondria/virus 443 - 926 IPR004868
conserved_site DNA-directed DNA polymerase, family B, conserved site 1010 - 1018 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Host nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

4 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

2 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
viral DNA strand displacement replication A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALVQAHRAR RLHAEAPDSG DQPPRRRVRQ QPPRAAPAPA RARRRRAPAP SPGGSRAPPT
70 80 90 100 110 120
SGGPPASPLL DASSKDTPAA HRPPRGTVVA PRGCGLLQVI DAATNQPLEI RYHLDLARAL
130 140 150 160 170 180
TRLCEVNLQE LPPDLSPREL QTMDSSHLRD VVIKLRPPRA DIWTLGSRGV VVRSTITPLE
190 200 210 220 230 240
QPDGQGQAAE VEDHQPNPPG EGLKFPLCFL VRGRQVNLVQ DVQPVHRCQY CARFYKSQHE
250 260 270 280 290 300
CSARRRDFYF HHINSHSSNW WREIQFFPIG SHPRTERLFV TYDVETYTWM GAFGKQLVPF
310 320 330 340 350 360
MLVMKFGGDE PLVTAARDLA VDLGWDRWEQ DPLTFYCITP EKMAIGRQFR TFRDHLQMLM
370 380 390 400 410 420
ARDLWSSFVA SNPHLADWAL SEHGLSSPEE LTYEELKKLP SIKGTPRFLE LYIVGHNING
430 440 450 460 470 480
FDEIVLAAQV INNRSEVPGP FRITRNFMPR AGKILFNDVT FALPNPRSKK RTDFLLWEQG
490 500 510 520 530 540
GCDDTDFKYQ YLKVMVRDTF ALTHTSLRKA AQAYALPVEK GCCAYQAVNQ FYMLGSYRSE
550 560 570 580 590 600
ADGFPIQEYW KDREEFVLNR ELWKKKGQDK YDIIKETLDY CALDVQVTAE LVNKLRDSYA
610 620 630 640 650 660
SFVRDAVGLT DASFNVFQRP TISSNSHAIF RQIVFRAEQP ARSNLGPDLL APSHELYDYV
670 680 690 700 710 720
RASIRGGRCY PTYLGILREP LYVYDICGMY ASALTHPMPW GPPLNPYERA LAARAWQQAL
730 740 750 760 770 780
DLQGCKIDYF DARLLPGVFT VDADPPDETQ LDPLPPFCSR KGGRLCWTNE RLRGEVATSV
790 800 810 820 830 840
DLVTLHNRGW RVHLVPDERT TVFPEWRCVA REYVQLNIAA KERADRDKNQ TLRSIAKLLS
850 860 870 880 890 900
NALYGSFATK LDNKKIVFSD QMDAATLKGI TAGQVNIKSS SFLETDNLSA EVMPAFEREY
910 920 930 940 950 960
SPQQLALADS DAEESEDERA PTPFYSPPSG TPGHVAYTYK PITFLDAEEG DMCLHTLERV
970 980 990 1000 1010 1020
DPLVDNDRYP SHLASFVLAW TRAFVSEWSE FLYEEDRGTP LEDRPLKSVY GDTDSLFVTE
1030 1040 1050 1060 1070 1080
RGHRLMETRG KKRIKKHGGN LVFDPERPEL TWLVECETVC GACGADAYSP ESVFLAPKLY
1090 1100 1110 1120 1130 1140
ALKSLHCPSC GASSKGKLRA KGHAAEGLDY DTMVKCYLAD AQGEDRQRFS TSRTSLKRTL
1150 1160 1170 1180 1190
ASAQPGAHPF TVTQTTLTRT LRPWKDMTLA RLDEHRLLPY SESRPNPRNE EICWIEMP