P03247

PR
Gene name
E1B
Protein name
E1B protein, small T-antigen
Names
E1B 19 kDa protein, E1B-19K, E1B-175R
Species
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

111-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P03247

Entry ID Method Resolution Chain Position Source

No variants for P03247

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P03247

No associated diseases with P03247

4 regional properties for P03247

Type Name Position InterPro Accession
domain DNA helicase E1, C-terminal, Papillomavirus 308 - 595 IPR001177
domain DNA helicase E1, N-terminal, Papillomavirus 1 - 117 IPR014000
domain Helicase, superfamily 3, DNA virus 406 - 556 IPR014015
domain DNA helicase E1, DNA-binding domain, papillomavirus 168 - 302 IPR046832

Functions

Description
EC Number
Subcellular Localization
  • Host cell membrane
  • Host nucleus envelope
  • Host nucleus lamina
  • Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
host cell endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
host cell nuclear envelope The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
host cell nuclear lamina The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments.
host cell plasma membrane The plasma membrane surrounding a host cell.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
suppression by virus of host apoptotic process Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEAWECLEDF SAVRNLLEQS SNSTSWFWRF LWGSSQAKLV CRIKEDYKWE FEELLKSCGE
70 80 90 100 110 120
LFDSLNLGHQ ALFQEKVIKT LDFSTPGRAA AAVAFLSFIK DKWSEETHLS GGYLLDFLAM
130 140 150 160 170
HLWRAVVRHK NRLLLLSSVR PAIIPTEEQQ QEEARRRRRQ EQSPWNPRAG LDPRE