P02929

PR
Gene name
tonB (exbA, b1252, JW5195)
Protein name
Protein TonB
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1252
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for P02929

Entry ID Method Resolution Chain Position Source
1IHR X-ray 155 A A/B 164-239 PDB
1QXX X-ray 270 A A 164-239 PDB
1U07 X-ray 113 A A/B 150-239 PDB
1XX3 NMR - A 103-239 PDB
2GRX X-ray 330 A C/D 31-239 PDB
2GSK X-ray 210 A B 153-233 PDB
8P9R X-ray 152 A C 40-62 PDB
8VGC X-ray 142 A P 43-52 PDB
8VGD X-ray 142 A P 43-51 PDB
AF-P02929-F1 Predicted AlphaFoldDB

8 variants for P02929

Variant ID(s) Position Change Description Diseaes Association Provenance
51 T>A strain: ECOR 28, ECOR 31, ECOR 37, ECOR 46, ECOR 50, ECOR 52, ECOR 60 and ECOR 71 [UniProt] No
70 E>K strain: ECOR 31 [UniProt] No
87 V>A strain: ECOR 37 and ECOR 71 [UniProt] No
102 P>PKP strain: ECOR 50 [UniProt] No
107 Q>del strain: ECOR 52 and ECOR 60 [UniProt] No
114 V>I strain: ECOR 28 [UniProt] No
133 L>P strain: ECOR 16, ECOR 31, ECOR 46, ECOR 50, ECOR 52 and ECOR 60 [UniProt] No
176 V>I strain: ECOR 60 [UniProt] No

No associated diseases with P02929

2 regional properties for P02929

Type Name Position InterPro Accession
domain TonB/TolA, C-terminal 161 - 233 IPR006260
domain TonB, C-terminal 160 - 228 IPR037682

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane; Single-pass membrane protein; Periplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell envelope An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
cell outer membrane A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
integral component of external side of plasma membrane The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasma membrane protein complex Any protein complex that is part of the plasma membrane.
transmembrane transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.

3 GO annotations of molecular function

Name Definition
energy transducer activity The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.
protein domain specific binding Binding to a specific domain of a protein.
siderophore transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).

7 GO annotations of biological process

Name Definition
cobalamin transport The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
colicin transport The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1.
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
receptor-mediated bacteriophage irreversible attachment to host cell The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell.
siderophore transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTLDLPRRFP WPTLLSVCIH GAVVAGLLYT SVHQVIELPA PAQPISVTMV TPADLEPPQA
70 80 90 100 110 120
VQPPPEPVVE PEPEPEPIPE PPKEAPVVIE KPKPKPKPKP KPVKKVQEQP KRDVKPVESR
130 140 150 160 170 180
PASPFENTAP ARLTSSTATA ATSKPVTSVA SGPRALSRNQ PQYPARAQAL RIEGQVKVKF
190 200 210 220 230
DVTPDGRVDN VQILSAKPAN MFEREVKNAM RRWRYEPGKP GSGIVVNILF KINGTTEIQ