P02920
Gene name |
lacY |
Protein name |
Lactose permease |
Names |
Lactose-proton symport |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b0343 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
11 structures for P02920
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1PV6 | X-ray | 350 A | A/B | 1-417 | PDB |
| 1PV7 | X-ray | 360 A | A/B | 1-417 | PDB |
| 2CFP | X-ray | 330 A | A | 1-417 | PDB |
| 2CFQ | X-ray | 295 A | A | 1-417 | PDB |
| 2V8N | X-ray | 360 A | A/B | 1-417 | PDB |
| 2Y5Y | X-ray | 338 A | A/B | 1-417 | PDB |
| 4ZYR | X-ray | 331 A | A/B | 1-417 | PDB |
| 5GXB | X-ray | 330 A | A | 1-417 | PDB |
| 6C9W | X-ray | 300 A | A | 1-417 | PDB |
| 6VBG | X-ray | 280 A | A/B | 1-417 | PDB |
| AF-P02920-F1 | Predicted | AlphaFoldDB |
No variants for P02920
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P02920 | |||||
No associated diseases with P02920
3 regional properties for P02920
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | LacY/RafB permease family, conserved site | 64 - 78 | IPR018457-1 |
| conserved_site | LacY/RafB permease family, conserved site | 280 - 294 | IPR018457-2 |
| domain | Major facilitator superfamily domain | 8 - 404 | IPR020846 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| carbohydrate:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). |
| lactose binding | Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk. |
| lactose:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate transport | The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. |
| lactose transport | The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. |
| organic substance transport | The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYYLKNTNFW | MFGLFFFFYF | FIMGAYFPFF | PIWLHDINHI | SKSDTGIIFA | AISLFSLLFQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLFGLLSDKL | GLRKYLLWII | TGMLVMFAPF | FIFIFGPLLQ | YNILVGSIVG | GIYLGFCFNA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAPAVEAFIE | KVSRRSNFEF | GRARMFGCVG | WALCASIVGI | MFTINNQFVF | WLGSGCALIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVLLFFAKTD | APSSATVANA | VGANHSAFSL | KLALELFRQP | KLWFLSLYVI | GVSCTYDVFD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QQFANFFTSF | FATGEQGTRV | FGYVTTMGEL | LNASIMFFAP | LIINRIGGKN | ALLLAGTIMS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRIIGSSFAT | SALEVVILKT | LHMFEVPFLL | VGCFKYITSQ | FEVRFSATIY | LVCFCFFKQL |
| 370 | 380 | 390 | 400 | 410 | |
| AMIFMSVLAG | NMYESIGFQG | AYLVLGLVAL | GFTLISVFTL | SGPGPLSLLR | RQVNEVA |