P02662
PR
Gene name |
CSN1S1 |
Protein name |
Alpha-S1-casein |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282208 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P02662
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P02662-F1 | Predicted | AlphaFoldDB |
28 variants for P02662
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs451922972 | 17 | P>R | No | EVA | |
| rs452361586 | 18 | K>I | No | EVA | |
| 29 | E>del | variant A [UniProt] | No | ||
| rs458440523 | 55 | L>Q | No | EVA | |
| rs476159726 | 56 | S>I | No | EVA | |
| rs443238143 | 57 | K>E | No | EVA | |
| rs455234382 | 58 | D>E | No | EVA | |
| rs473784258 | 61 | S>G | No | EVA | |
| rs440768186 | 61 | S>R | No | EVA | |
| rs452861688 | 63 | S>P | No | EVA | |
| rs471325891 | 65 | E>G | No | EVA | |
| rs433385179 | 68 | A>T | variant D [UniProt] | No | EVA |
| rs455798563 | 75 | M>T | No | EVA | |
| rs481805206 | 87 | V>I | No | EVA | |
| rs132656458 | 91 | V>A | No | EVA | |
| rs132656458 | 91 | V>D | No | EVA | |
| rs460181134 | 92 | E>A | No | EVA | |
| rs478696400 | 92 | E>D | No | EVA | |
| rs472158476 | 96 | I>V | No | EVA | |
| rs439241173 | 98 | K>N | No | EVA | |
| rs718752352 | 99 | E>D | No | EVA | |
| rs457749087 | 102 | P>L | No | EVA | |
| rs449797514 | 106 | Y>S | No | EVA | |
| rs109112922 | 108 | G>S | No | EVA | |
| rs478380813 | 116 | L>V | No | EVA | |
| rs110981354 | 155 | Q>H | No | EVA | |
| rs3423094759 | 182 | V>F | No | EVA | |
| rs43703010 | 207 | E>G | variant C [UniProt] | No | EVA |
No associated diseases with P02662
1 regional properties for P02662
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Casein alpha/beta, conserved site | 8 - 15 | IPR031305 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi lumen | The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| amyloid-beta binding | Binding to an amyloid-beta peptide/protein. |
| antioxidant activity | Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of supramolecular fiber organization | Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. |
| positive regulation of androst-4-ene-3,17-dione biosynthetic process | Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process. |
| positive regulation of androstenedione secretion | Any process that activates or increases the frequency, rate or extent of androstenedione secretion. |
| positive regulation of progesterone biosynthetic process | Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process. |
| positive regulation of progesterone secretion | Any process that activates or increases the frequency, rate or extent of progesterone secretion. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| response to 11-deoxycorticosterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus. |
| response to dehydroepiandrosterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus. |
| response to estradiol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| response to growth hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. |
| response to progesterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39035 | CSN1S1 | Alpha-S1-casein | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLLILTCLV | AVALARPKHP | IKHQGLPQEV | LNENLLRFFV | APFPEVFGKE | KVNELSKDIG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SESTEDQAME | DIKQMEAESI | SSSEEIVPNS | VEQKHIQKED | VPSERYLGYL | EQLLRLKKYK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPQLEIVPNS | AEERLHSMKE | GIHAQQKEPM | IGVNQELAYF | YPELFRQFYQ | LDAYPSGAWY |
| 190 | 200 | 210 | |||
| YVPLGTQYTD | APSFSDIPNP | IGSENSEKTT | MPLW |