Descriptions
TLR7 (Toll-like receptor 7) is an endosomal receptor that plays a key role in innate and adaptive immunity by recognizing pathogen-associated molecular patterns. TLR7 triggers antiviral immune responses by recognizing viral single-stranded RNA in endosomes. TLR7 is a type I transmembrane protein characterized by an extracellular leucine-rich repeat (LRR) domain, a transmembrane helix, and an intracellular Toll/interleukin-1 receptor (TIR) homology domain. Upon binding to agonists, TLR7 undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. TLR7 is also proteolytically cleaved in different human immune and nonimmune cells and that cleavage processing is required for functional activity. TLR7 cleavage generates within the loop between LRRs 14 and 15 and requires calcium-dependent serine proteases of the furin-like PC family.
Autoinhibitory domains (AIDs)
Target domain |
80-784 (Myosin head, motor domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P02565
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P02565-F1 | Predicted | AlphaFoldDB |
1 variants for P02565
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 379 | G>D | No |
No associated diseases with P02565
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| myofibril | The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. |
| myosin filament | A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. |
| myosin II complex | A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| microfilament motor activity | A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| muscle contraction | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
46 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27991 | MYH10 | Myosin-10 | Bos taurus (Bovine) | SS |
| Q9BE39 | MYH7 | Myosin-7 | Bos taurus (Bovine) | SS |
| Q9BE40 | MYH1 | Myosin-1 | Bos taurus (Bovine) | SS |
| Q9BE41 | MYH2 | Myosin-2 | Bos taurus (Bovine) | SS |
| P13538 | Myosin heavy chain, skeletal muscle, adult | Gallus gallus (Chicken) | SS | |
| P14105 | MYH9 | Myosin-9 | Gallus gallus (Chicken) | SS |
| P10587 | MYH11 | Myosin-11 | Gallus gallus (Chicken) | SS |
| Q99323 | zip | Myosin heavy chain, non-muscle | Drosophila melanogaster (Fruit fly) | SS |
| P05661 | Mhc | Myosin heavy chain, muscle | Drosophila melanogaster (Fruit fly) | SS |
| P35579 | MYH9 | Myosin-9 | Homo sapiens (Human) | SS |
| A7E2Y1 | MYH7B | Myosin-7B | Homo sapiens (Human) | SS |
| Q9Y2K3 | MYH15 | Myosin-15 | Homo sapiens (Human) | SS |
| P12883 | MYH7 | Myosin-7 | Homo sapiens (Human) | EV |
| P35580 | MYH10 | Myosin-10 | Homo sapiens (Human) | SS |
| P35749 | MYH11 | Myosin-11 | Homo sapiens (Human) | SS |
| P13533 | MYH6 | Myosin-6 | Homo sapiens (Human) | SS |
| Q9UKX3 | MYH13 | Myosin-13 | Homo sapiens (Human) | SS |
| P11055 | MYH3 | Myosin-3 | Homo sapiens (Human) | SS |
| Q7Z406 | MYH14 | Myosin-14 | Homo sapiens (Human) | SS |
| P12882 | MYH1 | Myosin-1 | Homo sapiens (Human) | SS |
| P13535 | MYH8 | Myosin-8 | Homo sapiens (Human) | SS |
| Q9Y623 | MYH4 | Myosin-4 | Homo sapiens (Human) | SS |
| Q9UKX2 | MYH2 | Myosin-2 | Homo sapiens (Human) | SS |
| Q8VDD5 | Myh9 | Myosin-9 | Mus musculus (Mouse) | SS |
| Q02566 | Myh6 | Myosin-6 | Mus musculus (Mouse) | SS |
| O08638 | Myh11 | Myosin-11 | Mus musculus (Mouse) | SS |
| A2AQP0 | Myh7b | Myosin-7B | Mus musculus (Mouse) | SS |
| Q61879 | Myh10 | Myosin-10 | Mus musculus (Mouse) | SS |
| Q91Z83 | Myh7 | Myosin-7 | Mus musculus (Mouse) | SS |
| Q6URW6 | Myh14 | Myosin-14 | Mus musculus (Mouse) | SS |
| P13541 | Myh3 | Myosin-3 | Mus musculus (Mouse) | SS |
| P13542 | Myh8 | Myosin-8 | Mus musculus (Mouse) | SS |
| Q5SX39 | Myh4 | Myosin-4 | Mus musculus (Mouse) | SS |
| Q5SX40 | Myh1 | Myosin-1 | Mus musculus (Mouse) | SS |
| P79293 | MYH7 | Myosin-7 | Sus scrofa (Pig) | SS |
| Q9TV63 | MYH2 | Myosin-2 | Sus scrofa (Pig) | SS |
| P12847 | Myh3 | Myosin-3 | Rattus norvegicus (Rat) | SS |
| P02563 | Myh6 | Myosin-6 | Rattus norvegicus (Rat) | SS |
| P02564 | Myh7 | Myosin-7 | Rattus norvegicus (Rat) | SS |
| Q62812 | Myh9 | Myosin-9 | Rattus norvegicus (Rat) | SS |
| Q9JLT0 | Myh10 | Myosin-10 | Rattus norvegicus (Rat) | SS |
| Q29RW1 | Myh4 | Myosin-4 | Rattus norvegicus (Rat) | SS |
| P02566 | unc-54 | Myosin-4 | Caenorhabditis elegans | SS |
| P02567 | myo-1 | Myosin-1 | Caenorhabditis elegans | SS |
| P12844 | myo-3 | Myosin-3 | Caenorhabditis elegans | SS |
| P12845 | myo-2 | Myosin-2 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFSMWTRKR | QILIFLNMLL | VSRVFGFRWF | PKTLPCEVKV | NIPEAHVIVD | CTDKHLTEIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EGIPTNTTNL | TLTINHIPSI | SPDSFRRLNH | LEEIDLRCNC | VPVLLGSKAN | VCTKRLQIRP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GSFSGLSDLK | ALYLDGNQLL | EIPQDLPSSL | HLLSLEANNI | FSITKENLTE | LVNIETLYLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QNCYYRNPCN | VSYSIEKDAF | LVMRNLKVLS | LKDNNVTAVP | TTLPPNLLEL | YLYNNIIKKI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QENDFNNLNE | LQVLDLSGNC | PRCYNVPYPC | TPCENNSPLQ | IHDNAFNSLT | ELKVLRLHSN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLQHVPPTWF | KNMRNLQELD | LSQNYLAREI | EEAKFLHFLP | NLVELDFSFN | YELQVYHASI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLPHSLSSLE | NLKILRVKGY | VFKELKNSSL | SVLHKLPRLE | VLDLGTNFIK | IADLNIFKHF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ENLKLIDLSV | NKISPSEESR | EVGFCPNAQT | SVDRHGPQVL | EALHYFRYDE | YARSCRFKNK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EPPSFLPLNA | DCHIYGQTLD | LSRNNIFFIK | PSDFQHLSFL | KCLNLSGNTI | GQTLNGSELW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PLRELRYLDF | SNNRLDLLYS | TAFEELQSLE | VLDLSSNSHY | FQAEGITHML | NFTKKLRLLD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KLMMNDNDIS | TSASRTMESD | SLRILEFRGN | HLDVLWRAGD | NRYLDFFKNL | FNLEVLDISR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NSLNSLPPEV | FEGMPPNLKN | LSLAKNGLKS | FFWDRLQLLK | HLEILDLSHN | QLTKVPERLA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NCSKSLTTLI | LKHNQIRQLT | KYFLEDALQL | RYLDISSNKI | QVIQKTSFPE | NVLNNLEMLV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LHHNRFLCNC | DAVWFVWWVN | HTDVTIPYLA | TDVTCVGPGA | HKGQSVISLD | LYTCELDLTN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LILFSVSISS | VLFLMVVMTT | SHLFFWDMWY | IYYFWKAKIK | GYQHLQSMES | CYDAFIVYDT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KNSAVTEWVL | QELVAKLEDP | REKHFNLCLE | ERDWLPGQPV | LENLSQSIQL | SKKTVFVMTQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KYAKTESFKM | AFYLSHQRLL | DEKVDVIILI | FLEKPLQKSK | FLQLRKRLCR | SSVLEWPANP |
| 1030 | 1040 | ||||
| QAHPYFWQCL | KNALTTDNHV | AYSQMFKETV |