Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P01754
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P01754-F1 | Predicted | AlphaFoldDB |
27 variants for P01754
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1133240891 | 5 | C>Y | No | EVA | |
| rs1134158088 | 7 | M>I | No | EVA | |
| rs48301615 | 11 | A>V | No | EVA | |
| rs3389276334 | 12 | A>T | No | EVA | |
| rs108652427 | 16 | G>D | No | EVA | |
| rs587328172 | 19 | F>C | No | EVA | |
| rs587328172 | 19 | F>S | No | EVA | |
| rs1133028524 | 28 | A>S | No | EVA | |
| rs1133752126 | 32 | K>R | No | EVA | |
| rs3403807119 | 36 | S>P | No | EVA | |
| rs581539032 | 41 | S>C | No | EVA | |
| rs3389195214 | 49 | T>I | No | EVA | |
| rs1135332167 | 54 | H>N | No | EVA | |
| rs586777915 | 62 | R>Q | No | EVA | |
| rs583443918 | 69 | R>G | No | EVA | |
| rs579708665 | 69 | R>K | No | EVA | |
| rs583443918 | 69 | R>W | No | EVA | |
| rs585470875 | 71 | D>N | No | EVA | |
| rs585470875 | 71 | D>Y | No | EVA | |
| rs1131987671 | 73 | N>Y | No | EVA | |
| rs583013514 | 78 | K>N | No | EVA | |
| rs1135162180 | 78 | K>R | No | EVA | |
| rs1132521482 | 79 | Y>* | No | EVA | |
| rs1132708304 | 79 | Y>F | No | EVA | |
| rs3389268030 | 85 | S>G | No | EVA | |
| rs1133752042 | 94 | P>S | No | EVA | |
| rs579578594 | 116 | A>T | No | EVA |
No associated diseases with P01754
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| immunoglobulin complex, circulating | An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| antigen binding | Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. |
| immunoglobulin receptor binding | Binding to one or more specific sites on an immunoglobulin receptor molecule. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| B cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. |
| complement activation, classical pathway | Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| phagocytosis, engulfment | The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. |
| phagocytosis, recognition | The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. |
| positive regulation of B cell activation | Any process that activates or increases the frequency, rate or extent of B cell activation. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGWSCIMLFL | AATATGVHFQ | VQLQQPGAEL | VKPGASVKLS | SKASGYTFTS | YWMHWVKQRP |
| 70 | 80 | 90 | 100 | 110 | |
| GRGLEWIGRI | DPNSGGTKYN | EKFKSKATLT | VDKPSSTAYM | QLSSLTSEDS | AVYYCAR |