Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P01105
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
1 variants for P01105
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 628 | H>D | mutant TS1.1 [UniProt] | No |
No associated diseases with P01105
5 regional properties for P01105
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ets domain | 559 - 644 | IPR000418 |
| domain | Pointed domain | 276 - 361 | IPR003118 |
| domain | Transcription regulator Wos2-domain | 83 - 128 | IPR012642 |
| domain | Protein C-ets-1, pointed domain | 276 - 363 | IPR041886 |
| domain | Ets1, N-terminal flanking region of Ets domain | 373 - 556 | IPR045688 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| NSTMRRKVEQ | EGYLQESSKA | GLPSATTGFQ | KSSHLMAFAH | NPPAGPLPGA | GQAPLGSDYP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YYHIAEPQNV | PGQIPYPVAL | HVNIVNVPQP | AAAAIQRHYN | DEDPEKEKRI | KELELLLMST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENELKGQQAL | PTQNHTANYP | GWHSTTVADN | TMTSGDNAPV | SCLGEHHHCT | PSPPVDHGTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EMMSYYMDTT | IGSTGPYPLA | RPGVMQGASS | CCEDPWMPCR | LQSACCPPRS | CCPPWDEAAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QEVPTGLEHY | STDMECADVP | LLTPSSKEMM | SQALKATFSG | FAKEQQRLGI | PKDPQQWTET |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HVRDWVMWAV | NEFSLKGVDF | QKFCMNGAAL | CALGKECFLE | LAPDFVGDIL | WEHLEILQKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAKPYPANGV | NAAYPESRYT | SDYFISYGIE | HAQCVPPSEF | SEPSFITESY | QTLHPISSEE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLSLKYENDY | PSVILRDPVQ | TDSLQTDYFT | IKQEVVTPDN | MCMGRVSRGK | LGGQDSFESI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ESYDSCDRLT | QSWSSQSSFQ | SLQRVPSYDS | FDSEDYPAAL | PNHKPKGTFK | DYVRDRADMN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDKPVIPAAA | LAGYTGSGPI | QLWQFLLELL | TDKSCQSFIS | WTGDGWEFKL | SDPDEVARRW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GKRKNKPKMD | YEKLSRGLRY | YYDKNVIHKT | AGKRYVYRFV | CDLQSLLGYT | PEEHSSASGL |
| TSSMACSSF |