P01025

PR
Gene name
C3
Protein name
Complement C3
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397072
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P01025

Entry ID Method Resolution Chain Position Source
AF-P01025-F1 Predicted AlphaFoldDB

No variants for P01025

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P01025

No associated diseases with P01025

17 regional properties for P01025

Type Name Position InterPro Accession
domain Anaphylatoxin/fibulin 676 - 745 IPR000020
domain Netrin domain 1516 - 1659 IPR001134
domain Alpha-2-macroglobulin 768 - 864 IPR001599
domain Anaphylatoxin, complement system domain 687 - 696 IPR001840-1
domain Anaphylatoxin, complement system domain 704 - 715 IPR001840-2
domain Anaphylatoxin, complement system domain 717 - 728 IPR001840-3
domain Macroglobulin domain 129 - 223 IPR002890
domain Alpha-macroglobulin, receptor-binding 1395 - 1492 IPR009048
domain Alpha-2-macroglobulin, bait region domain 454 - 603 IPR011625
domain Alpha-macroglobulin-like, TED domain 994 - 1280 IPR011626
domain Netrin module, non-TIMP type 1531 - 1643 IPR018933
conserved_site Alpha-2-macroglobulin, conserved site 1005 - 1013 IPR019742
domain Complement C3-like, NTR domain 1511 - 1659 IPR035815
domain Macroglobulin domain MG4 354 - 444 IPR040839
domain Complement C3/4/5, macroglobulin domain MG1 24 - 123 IPR041425
domain Macroglobulin domain MG3 225 - 302 IPR041555
conserved_site Alpha-macroglobulin-like, thiol-ester bond-forming region 997 - 1026 IPR047565

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
C5L2 anaphylatoxin chemotactic receptor binding Binding to a C5L2 anaphylatoxin chemotactic receptor.
endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

10 GO annotations of biological process

Name Definition
complement activation, alternative pathway Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
complement activation, classical pathway Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
positive regulation of glucose transmembrane transport Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of lipid storage Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of triglyceride biosynthetic process Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSTSGPRLL LLLLTSLPLA LGDPIYTIIT PNVLRLESEE MVVLEAHEGQ GDIRVSVTVH
70 80 90 100 110 120
DFPAKRQVLS SETTTLNNAN NYLSTVNIKI PASKEFKSEK GHKFVTVQAL FGNVQVEKVV
130 140 150 160 170 180
LVSLQSGYLF IQTDKTIYTP GSTVLYRIFT VDHKLLPVGQ TIVVTIETPE GIDIKRDSLS
190 200 210 220 230 240
SHNQFGILAL SWNIPELVNM GQWKIRAHYE DAPQQVFSAE FEVKEYVLPS FEVQVEPSEK
250 260 270 280 290 300
FYYIDDPNGL TVNIIARFLY GESVDGTAFV IFGVQDGDQR ISLSQSLTRV PIIDGTGEAT
310 320 330 340 350 360
LSQGVLLNGV HYSSVNDLVG KSIYVSVTVI LNSGSDMVEA ERTGIPIVTS PYQIHFTKTP
370 380 390 400 410 420
KFFKPAMPFD LMVYVTNPDG SPARHIPVVT EDFKVRSLTQ EDGVAKLSIN TPDNRNSLPI
430 440 450 460 470 480
TVRTEKDGIP AARQASKTMH VLPYNTQGNS KNYLHLSLPR VELKPGENLN VNFHLRTDPG
490 500 510 520 530 540
YQDKIRYFTY LIMNKGKLLK VGRQPRESGQ VVVVLPLTIT TDFIPSFRLV AYYTLIAANG
550 560 570 580 590 600
QREVVADSVW VDVKDSCVGT LVVKGGGKQD KQHRPGQQMT LEIQGERGAR VGLVAVDKGV
610 620 630 640 650 660
FVLNKKNKLT QRRIWDVVEK ADIGCTPGSG KDFAGVFTDA GLAFKSSKGL QTPQRADLEC
670 680 690 700 710 720
PKPAARKRRS VQLMEKRMDK LGQYSKDVRR CCEHGMRDNP MKFSCQRRAQ FIQHGDACVK
730 740 750 760 770 780
AFLDCCEYIA KLRQQHSRNK PLGLARSDLD EEIIPEEDII SRSQFPESWL WTIEEFKEPD
790 800 810 820 830 840
KNGISTKTMN VFLKDSITTW EILAVSLSDK KGICVADPYE VVVKQDFFID LRLPYSVVRN
850 860 870 880 890 900
EQVEIRAILY NYREAEDLKV RVELLYNPAF CSLATAKKRH QQTLTVPAKS SVPVPYIIVP
910 920 930 940 950 960
LKTGLQEVEV KAAVYNHFIS DGVKKTLKVV PEGMRVNKTV VTRTLDPEHK GQQGVQREEI
970 980 990 1000 1010 1020
PPADLSDQVP DTESETKILL QGTPVAQMVE DAIDGDRLKH LIQTPSGCGE QNMIGMTPTV
1030 1040 1050 1060 1070 1080
IAVHYLDSTE QWEKFGLEKR QEALELIKKG YTQQLAFRQK NSAFAAFQDR LSSTLLTAYV
1090 1100 1110 1120 1130 1140
VKVFAMAANL IAIDSQVLCG AVKWLILEKQ KPDGVFEENG PVIHQEMIGG FKNTEEKDVS
1150 1160 1170 1180 1190 1200
LTAFVLIALQ EAKDICEPQV NSLLRSINKA RDFLADYYLE LKRPYTVAIA GYALALSDKL
1210 1220 1230 1240 1250 1260
DEPFLNKLLS TAKERNRWEE PGQKLHNVEA TSYALLALLV VKDFDSVPPI VRWLNEQRYY
1270 1280 1290 1300 1310 1320
GGGYGSTQAT FMVFQALAQY QKDVPDHKDL NLDVSIHLPS RSAPVRHRIL WESASLLRSE
1330 1340 1350 1360 1370 1380
ETKENEGFTL IAEGKGQGTL SVVTMYHGKA KGKTTCKKFD LKVSIHPAPE PVKKPQEAKS
1390 1400 1410 1420 1430 1440
SMVLDICTRY LGNQDATMSI LDISMMTGFS PDTEDLKLLS TGVDRYISKY ELNKALSNKN
1450 1460 1470 1480 1490 1500
TLIIYLDKIS HTLEDCISFK VHQYFNVGLI QPGSVKVYSY YNLDESCTRF YHPEKEDGML
1510 1520 1530 1540 1550 1560
NKLCHKEMCR CAEENCFMHH DEEEVTLDDR LERACEPGVD YVYKTRLLKK ELSDDFDDYI
1570 1580 1590 1600 1610 1620
MVIEQIIKSG SDEVQVGQER RFISHIKCRE ALKLKEGGHY LVWGVSSDLW GEKPNISYII
1630 1640 1650 1660
GKDTWVELWP DGDVCQDEEN QKQCQDLANF SENMVVFGCP N