P00970
Gene name |
30 |
Protein name |
DNA ligase |
Names |
Polydeoxyribonucleotide synthase [ATP] |
Species |
Enterobacteria phage T4 (Bacteriophage T4) |
KEGG Pathway |
vg:1258680 |
EC number |
6.5.1.1: Forming phosphoric ester bonds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
No variants for P00970
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00970 | |||||
No associated diseases with P00970
3 regional properties for P00970
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA ligase, ATP-dependent, central | 135 - 367 | IPR012310 |
| conserved_site | DNA ligase, ATP-dependent, conserved site | 157 - 165 | IPR016059-1 |
| conserved_site | DNA ligase, ATP-dependent, conserved site | 344 - 367 | IPR016059-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.5.1.1 | Forming phosphoric ester bonds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| DNA ligase (ATP) activity | Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). |
| DNA ligase activity | Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MILKILNEIA | SIGSTKQKQA | ILEKNKDNEL | LKRVYRLTYS | RGLQYYIKKW | PKPGIATQSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GMLTLTDMLD | FIEFTLATRK | LTGNAAIEEL | TGYITDGKKD | DVEVLRRVMM | RDLECGASVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IANKVWPGLI | PEQPQMLASS | YDEKGINKNI | KFPAFAQLKA | DGARCFAEVR | GDELDDVRLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRAGNEYLGL | DLLKEELIKM | TAEARQIHPE | GVLIDGELVY | HEQVKKEPEG | LDFLFDAYPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NSKAKEFAEV | AESRTASNGI | ANKSLKGTIS | EKEAQCMKFQ | VWDYVPLVEI | YSLPAFRLKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DVRFSKLEQM | TSGYDKVILI | ENQVVNNLDE | AKVIYKKYID | QGLEGIILKN | IDGLWENARS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KNLYKFKEVI | DVDLKIVGIY | PHRKDPTKAG | GFILESECGK | IKVNAGSGLK | DKAGVKSHEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DRTRIMENQN | YYIGKILECE | CNGWLKSDGR | TDYVKLFLPI | AIRLREDKTK | ANTFEDVFGD |
| FHEVTGL |