P00953

PR
Gene name
trpS
Protein name
Tryptophan--tRNA ligase
Names
Tryptophanyl-tRNA synthetase, TrpRS
Species
Geobacillus stearothermophilus (Bacillus stearothermophilus)
KEGG Pathway
EC number
6.1.1.2: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

153-228 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

16 structures for P00953

Entry ID Method Resolution Chain Position Source
1D2R X-ray 290 A A/B/C/D/E/F 1-326 PDB
1I6K X-ray 172 A A 1-328 PDB
1I6L X-ray 172 A A 1-328 PDB
1I6M X-ray 172 A A 1-328 PDB
1M83 X-ray 220 A A 1-328 PDB
1MAU X-ray 215 A A 1-328 PDB
1MAW X-ray 300 A A/B/C/D/E/F 1-328 PDB
1MB2 X-ray 270 A A/B/C/D/E/F 1-328 PDB
2OV4 X-ray 250 A A 1-328 PDB
3FHJ X-ray 265 A A/B/C/D/E/F 1-326 PDB
3FI0 X-ray 270 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R 1-326 PDB
5DK4 X-ray 190 A A 2-328 PDB
7CKI X-ray 230 A A 1-328 PDB
7CMS X-ray 220 A A/B 1-328 PDB
7EER X-ray 200 A A/B/C/D 1-328 PDB
AF-P00953-F1 Predicted AlphaFoldDB

No variants for P00953

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P00953

No associated diseases with P00953

1 regional properties for P00953

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 10 - 19 IPR001412

Functions

Description
EC Number 6.1.1.2 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tryptophan-tRNA ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).

1 GO annotations of biological process

Name Definition
tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTIFSGIQP SGVITIGNYI GALRQFVELQ HEYNCYFCIV DQHAITVWQD PHELRQNIRR
70 80 90 100 110 120
LAAKYLAVGI DPTQATLFIQ SEVPAHAQAA WMLQCIVYIG ELERMTQFKE KSAGKEAVSA
130 140 150 160 170 180
GLLTYPPLMA ADILLYNTDI VPVGEDQKQH IELTRDLAER FNKRYGELFT IPEARIPKVG
190 200 210 220 230 240
ARIMSLVDPT KKMSKSDPNP KAYITLLDDA KTIEKKIKSA VTDSEGTIRY DKEAKPGISN
250 260 270 280 290 300
LLNIYSTLSG QSIEELERQY EGKGYGVFKA DLAQVVIETL RPIQERYHHW MESEELDRVL
310 320
DEGAEKANRV ASEMVRKMEQ AMGLGRRR