P00638
Gene name |
6 |
Protein name |
Exonuclease |
Names |
Exonuclease gp6, Gene product 6, Gp6 |
Species |
Escherichia phage T7 (Bacteriophage T7) |
KEGG Pathway |
vg:1261052 |
EC number |
3.1.11.3: Exodeoxyribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P00638
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P00638
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00638 | |||||
No associated diseases with P00638
1 regional properties for P00638
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 5'-3' exonuclease, alpha-helical arch, N-terminal | 78 - 165 | IPR020046 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.11.3 | Exodeoxyribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| RNA-DNA hybrid ribonuclease activity | Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| degradation of host chromosome by virus | The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis. |
| RNA phosphodiester bond hydrolysis, endonucleolytic | The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. |
| suppression by virus of host gene expression | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALLDLKQFY | ELREGCDDKG | ILVMDGDWLV | FQAMSAAEFD | ASWEEEIWHR | CCDHAKARQI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEDSIKSYET | RKKAWAGAPI | VLAFTDSVNW | RKELVDPNYK | ANRKAVKKPV | GYFEFLDALF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EREEFYCIRE | PMLEGDDVMG | VIASNPSAFG | ARKAVIISCD | KDFKTIPNCD | FLWCTTGNIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TQTEESADWW | HLFQTIKGDI | TDGYSGIAGW | GDTAEDFLNN | PFITEPKTSV | LKSGKNKGQE |
| 250 | 260 | 270 | 280 | 290 | |
| VTKWVKRDPE | PHETLWDCIK | SIGAKAGMTE | EDIIKQGQMA | RILRFNEYNF | IDKEIYLWRP |