P00534
Gene name |
V-ERBB |
Protein name |
Tyrosine-protein kinase transforming protein erbB |
Names |
|
Species |
Avian leukosis virus (ALV) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
274-299 (Activation loop from InterPro)
Target domain |
132-399 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
0 structures for P00534
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P00534
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00534 | |||||
No associated diseases with P00534
6 regional properties for P00534
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 132 - 399 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 134 - 387 | IPR001245 |
| active_site | Tyrosine-protein kinase, active site | 253 - 265 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 138 - 165 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 132 - 388 | IPR020635 |
| domain | Growth factor receptor domain 4 | 1 - 57 | IPR032778 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKCAHFIDGP | HCVKACPAGV | LGENDTLVWK | YADANAVCQL | CHPNCTRGCK | GPGLEGCPNG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKTPSIAAGV | VGGLLCLVVV | GLGIGLYLRR | RHIVRKRTLR | RLLQERELVE | PLTPSGEAPN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QAHLRILKET | EFKKVKVLGS | GAFGTVYKGL | WIPEGEKVKI | PVAIKELREA | TSPKANKEIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEAYVMASVD | NPHVCRLLGI | CLTSTVQLIT | QLMPYGCLLD | YIREHKDNIG | SQYLLNWCVQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IAKGMNYLEE | RRLVHRDLAA | RNVLVKTPQH | VKITDFGLAK | LLGADEKEYH | AEGGKVPIKW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MALESILHRI | YTHQSDVWSY | GVTVWELMTF | GSKPYDGIPA | SEISSVLEKG | ERLPQPPICT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IDVYMIMVKC | WMIDADSRPK | FRELIAEFSK | MARDPPRYLV | IQGDERMHLP | SPTDSKFYRT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LMEEEDMEDI | VDADEYLVPH | QGFFNSPSTS | RTPLLSSLSA | TSNNSATNCI | DRNGQGHPVR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EDSFVQRYSS | DPTGNFLEES | IDDGFLPAPE | YVNQLMPKKP | STAMVQNQIY | NNISLTAISK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LPMDSRYQNS | HSTAVDNPEY | LNTNQSPLAK | TVFESSPYWI | QSGNHQINLD | NPDYQQDFLP |
| 610 | 620 | 630 | |||
| NETKPNGLLK | VPAAENPEYL | RVAAPKSEYI | EASA |