P00532
Gene name |
V-RAF |
Protein name |
Serine/threonine-protein kinase-transforming protein raf |
Names |
|
Species |
Murine sarcoma virus 3611 |
KEGG Pathway |
|
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P00532
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P00532
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00532 | |||||
No associated diseases with P00532
4 regional properties for P00532
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 24 - 284 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 26 - 280 | IPR001245 |
| active_site | Serine/threonine-protein kinase, active site | 139 - 151 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 30 - 50 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| EKNKIRPRGQ | RDSSYYWKME | ASEVMLSTRI | GSGSFGTVYK | GKWHGDVAVK | ILKVVDPTPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLQAFRNEVA | VLRKTRHVNI | LLFMGYMTKD | NLAIVTQWCE | GSSLYKHLHV | QETKFQMFQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IDIARQTAQG | MDYLHAKNII | HRDMKSNNIF | LHEGLTVKIG | DFGLATVKSR | WSGSQQVEQP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGSVLWMAPE | VIRMQDDNPF | SFQSDVYSYG | IVLYELMAGE | LPYAHINNRD | QIIFMVGRGY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASPDLSRLYK | NCPKAIKRLV | ADCVKKVKEE | RPLFPQILSS | IELLQHSLPK | INRSAPEPSL |
| 310 | 320 | ||||
| HRAAHTEDIN | ACTLTTSPRL | PVF |